CXL14_MOUSE
ID CXL14_MOUSE Reviewed; 99 AA.
AC Q9WUQ5; Q548T5; Q91V02; Q9JHH7;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 23-MAR-2010, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=C-X-C motif chemokine 14;
DE AltName: Full=B-cell and monocyte-activating chemokine;
DE AltName: Full=Chemokine BRAK;
DE AltName: Full=Kidney-expressed chemokine CXC;
DE AltName: Full=MIP-2G;
DE AltName: Full=Small-inducible cytokine B14;
DE Flags: Precursor;
GN Name=Cxcl14; Synonyms=Bmac, Kec, Ks1, Mip2g, Scyb14;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10049774; DOI=10.1006/bbrc.1999.0257;
RA Hromas R., Broxmeyer H.E., Kim C., Nakshatri H., Christopherson K. II,
RA Azam M., Hou Y.-H.;
RT "Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed
RT in normal versus malignant cells.";
RL Biochem. Biophys. Res. Commun. 255:703-706(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=BALB/cByJ; TISSUE=Keratinocyte;
RX PubMed=10784614; DOI=10.1093/intimm/12.5.677;
RA Sleeman M.A., Fraser J.K., Murison J.G., Kelly S.L., Prestidge R.L.,
RA Palmer D.J., Watson J.D., Kumble K.D.;
RT "B cell- and monocyte-activating chemokine (BMAC), a novel non-ELR alpha-
RT chemokine.";
RL Int. Immunol. 12:677-689(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Kidney;
RX PubMed=10946286; DOI=10.4049/jimmunol.165.5.2588;
RA Cao X., Zhang W., Wan T., He L., Chen T., Yuan Z., Ma S., Yu Y., Chen G.;
RT "Molecular cloning and characterization of a novel CXC chemokine macrophage
RT inflammatory protein-2 gamma chemoattractant for human neutrophils and
RT dendritic cells.";
RL J. Immunol. 165:2588-2595(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C3H/HeJ;
RA Wang L., Deng L., Raikwar N., Sahota A., Tischfield J.A.;
RT "Identification of a kidney-expressed chemokine (KEC), a member of the CXC
RT family, that is selectively elevated in aprt knockout mice.";
RL Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.;
RT "Isolation of full-length cDNA clones from mouse brain cDNA library made by
RT oligo-capping method.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD;
RC TISSUE=Dendritic cell, Embryo, Embryonic head, and Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 5-99.
RC STRAIN=C57BL/6J; TISSUE=Fetus, and Placenta;
RA Schilderink N., Geerts D.;
RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Chemotactic for CESS B-cells and THP-1 monocytes, but not T-
CC cells. {ECO:0000269|PubMed:10784614}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Highly expressed in brain, lung, ovary, muscle and
CC in kidney and liver parenchyma, and at lower levels in bone marrow.
CC {ECO:0000269|PubMed:10784614, ECO:0000269|PubMed:10946286}.
CC -!- DOMAIN: The destruction box (D-box) acts as a recognition signal for
CC degradation via the ubiquitin-proteasome pathway. {ECO:0000250}.
CC -!- PTM: Ubiquitinated, followed by degradation by the proteasome.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC {ECO:0000305}.
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DR EMBL; AF152377; AAD34157.1; -; mRNA.
DR EMBL; AF144754; AAF66694.1; -; mRNA.
DR EMBL; AF252873; AAF65570.1; -; mRNA.
DR EMBL; AF192557; AAF03753.1; -; mRNA.
DR EMBL; AB041614; BAA95097.1; -; mRNA.
DR EMBL; AK004615; BAB23411.1; -; mRNA.
DR EMBL; AK014351; BAB29292.1; -; mRNA.
DR EMBL; AK076112; BAC36192.1; -; mRNA.
DR EMBL; AK155356; BAE33213.1; -; mRNA.
DR EMBL; CH466546; EDL41235.1; -; Genomic_DNA.
DR EMBL; BC147274; AAI47275.1; -; mRNA.
DR EMBL; BC147275; AAI47276.1; -; mRNA.
DR EMBL; AF352784; AAK52902.1; -; mRNA.
DR EMBL; AF352785; AAK52903.1; -; mRNA.
DR CCDS; CCDS36679.1; -.
DR RefSeq; NP_062514.2; NM_019568.2.
DR RefSeq; XP_006517371.1; XM_006517308.3.
DR AlphaFoldDB; Q9WUQ5; -.
DR SMR; Q9WUQ5; -.
DR STRING; 10090.ENSMUSP00000021970; -.
DR PhosphoSitePlus; Q9WUQ5; -.
DR MaxQB; Q9WUQ5; -.
DR PaxDb; Q9WUQ5; -.
DR PRIDE; Q9WUQ5; -.
DR ProteomicsDB; 283989; -.
DR Antibodypedia; 14757; 328 antibodies from 33 providers.
DR DNASU; 57266; -.
DR Ensembl; ENSMUST00000021970; ENSMUSP00000021970; ENSMUSG00000021508.
DR GeneID; 57266; -.
DR KEGG; mmu:57266; -.
DR UCSC; uc007qsm.2; mouse.
DR CTD; 9547; -.
DR MGI; MGI:1888514; Cxcl14.
DR VEuPathDB; HostDB:ENSMUSG00000021508; -.
DR eggNOG; ENOG502S4VP; Eukaryota.
DR GeneTree; ENSGT00390000000618; -.
DR HOGENOM; CLU_172940_1_0_1; -.
DR InParanoid; Q9WUQ5; -.
DR OMA; QYCLHPK; -.
DR OrthoDB; 1490790at2759; -.
DR PhylomeDB; Q9WUQ5; -.
DR TreeFam; TF332769; -.
DR BioGRID-ORCS; 57266; 6 hits in 75 CRISPR screens.
DR PRO; PR:Q9WUQ5; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q9WUQ5; protein.
DR Bgee; ENSMUSG00000021508; Expressed in gastrula and 252 other tissues.
DR ExpressionAtlas; Q9WUQ5; baseline and differential.
DR Genevisible; Q9WUQ5; MM.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0008009; F:chemokine activity; IEA:InterPro.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IDA:UniProtKB.
DR GO; GO:0048839; P:inner ear development; IDA:MGI.
DR GO; GO:0031640; P:killing of cells of another organism; IDA:UniProtKB.
DR GO; GO:0045662; P:negative regulation of myoblast differentiation; IMP:MGI.
DR GO; GO:2000503; P:positive regulation of natural killer cell chemotaxis; IMP:MGI.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR039088; CXCL14.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR15188; PTHR15188; 1.
DR Pfam; PF00048; IL8; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
PE 2: Evidence at transcript level;
KW Cytokine; Disulfide bond; Reference proteome; Secreted; Signal;
KW Ubl conjugation.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..99
FT /note="C-X-C motif chemokine 14"
FT /id="PRO_0000005116"
FT MOTIF 55..69
FT /note="D-box"
FT DISULFID 25..51
FT /evidence="ECO:0000250"
FT DISULFID 27..72
FT /evidence="ECO:0000250"
FT CONFLICT 17..20
FT /note="ASRV -> VRAL (in Ref. 1; AAD34157, 3; AAF65570 and
FT 4; AAF03753)"
FT /evidence="ECO:0000305"
FT CONFLICT 64
FT /note="S -> F (in Ref. 1; AAD34157 and 3; AAF65570)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 99 AA; 11716 MW; 97352E91FF7F46D6 CRC64;
MRLLAAALLL LLLALCASRV DGSKCKCSRK GPKIRYSDVK KLEMKPKYPH CEEKMVIVTT
KSMSRYRGQE HCLHPKLQST KRFIKWYNAW NEKRRVYEE
