CXL15_MOUSE
ID CXL15_MOUSE Reviewed; 167 AA.
AC Q9WVL7; Q3UQ15;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=C-X-C motif chemokine 15;
DE AltName: Full=Lungkine;
DE AltName: Full=Small-inducible cytokine B15;
DE Flags: Precursor;
GN Name=Cxcl15; Synonyms=Scyb15;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND INDUCTION.
RC TISSUE=Lung;
RX PubMed=10228029;
RA Rossi D.L., Hurst S.D., Xu Y., Wang W., Menon S., Coffman R.L., Zlotnik A.;
RT "Lungkine, a novel CXC chemokine, specifically expressed by lung
RT bronchoepithelial cells.";
RL J. Immunol. 162:5490-5497(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=11207292; DOI=10.4049/jimmunol.166.5.3362;
RA Chen S.C., Mehrad B., Deng J.C., Vassileva G., Manfra D.J., Cook D.N.,
RA Wiekowski M.T., Zlotnik A., Standiford T.J., Lira S.A.;
RT "Impaired pulmonary host defense in mice lacking expression of the CXC
RT chemokine lungkine.";
RL J. Immunol. 166:3362-3368(2001).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-157, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Chemotactic for neutrophils. Involved in lung-specific
CC neutrophil trafficking during normal and inflammatory conditions.
CC {ECO:0000269|PubMed:11207292}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10228029}.
CC -!- TISSUE SPECIFICITY: Expression restricted to the lung, produced by
CC bronchoepithelial cells and is released into the airways. Expressed at
CC low levels in fetal lung. {ECO:0000269|PubMed:10228029,
CC ECO:0000269|PubMed:11207292}.
CC -!- INDUCTION: By inflammation; in lung. {ECO:0000269|PubMed:10228029}.
CC -!- DISRUPTION PHENOTYPE: Mice develop normally and are fertile. They
CC display normal leukocyte subpopulations in peripheral blood and bone
CC marrow, but the amount of neutrophils is reduced in the airspace.
CC Susceptibility to pneumonia induced by K.pneumoniae is increased with
CC decreased survival and increased bacterial burden in lung.
CC {ECO:0000269|PubMed:11207292}.
CC -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF082859; AAD38079.1; -; mRNA.
DR EMBL; AK142955; BAE25229.1; -; mRNA.
DR EMBL; CH466617; EDL05302.1; -; Genomic_DNA.
DR EMBL; BC061138; AAH61138.1; -; mRNA.
DR CCDS; CCDS19418.1; -.
DR RefSeq; NP_035469.1; NM_011339.2.
DR AlphaFoldDB; Q9WVL7; -.
DR SMR; Q9WVL7; -.
DR STRING; 10090.ENSMUSP00000031322; -.
DR iPTMnet; Q9WVL7; -.
DR PhosphoSitePlus; Q9WVL7; -.
DR MaxQB; Q9WVL7; -.
DR PaxDb; Q9WVL7; -.
DR PeptideAtlas; Q9WVL7; -.
DR PRIDE; Q9WVL7; -.
DR ProteomicsDB; 279246; -.
DR DNASU; 20309; -.
DR Ensembl; ENSMUST00000031322; ENSMUSP00000031322; ENSMUSG00000029375.
DR GeneID; 20309; -.
DR KEGG; mmu:20309; -.
DR UCSC; uc008ybk.1; mouse.
DR CTD; 20309; -.
DR MGI; MGI:1339941; Cxcl15.
DR VEuPathDB; HostDB:ENSMUSG00000029375; -.
DR eggNOG; ENOG502TDRK; Eukaryota.
DR GeneTree; ENSGT00940000168732; -.
DR HOGENOM; CLU_1594012_0_0_1; -.
DR InParanoid; Q9WVL7; -.
DR OrthoDB; 1521563at2759; -.
DR PhylomeDB; Q9WVL7; -.
DR TreeFam; TF333433; -.
DR BioGRID-ORCS; 20309; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q9WVL7; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q9WVL7; protein.
DR Bgee; ENSMUSG00000029375; Expressed in left lung lobe and 44 other tissues.
DR Genevisible; Q9WVL7; MM.
DR GO; GO:0005576; C:extracellular region; IDA:MGI.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0008009; F:chemokine activity; IDA:MGI.
DR GO; GO:0045236; F:CXCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0006935; P:chemotaxis; IDA:MGI.
DR GO; GO:0030097; P:hemopoiesis; IDA:MGI.
DR GO; GO:0006954; P:inflammatory response; IDA:MGI.
DR GO; GO:0030593; P:neutrophil chemotaxis; IDA:MGI.
DR CDD; cd00273; Chemokine_CXC; 1.
DR InterPro; IPR001089; Chemokine_CXC.
DR InterPro; IPR018048; Chemokine_CXC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR033899; CXC_Chemokine_domain.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR10179; PTHR10179; 1.
DR Pfam; PF00048; IL8; 1.
DR PRINTS; PR00437; SMALLCYTKCXC.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
PE 1: Evidence at protein level;
KW Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW Phosphoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..167
FT /note="C-X-C motif chemokine 15"
FT /id="PRO_0000005117"
FT MOD_RES 157
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT DISULFID 30..57
FT /evidence="ECO:0000250"
FT DISULFID 32..73
FT /evidence="ECO:0000250"
SQ SEQUENCE 167 AA; 19091 MW; B9A724505FFDA5A8 CRC64;
MAAQGWSMLL LAVLNLGIFV RPCDTQELRC LCIQEHSEFI PLKLIKNIMV IFETIYCNRK
EVIAVPKNGS MICLDPDAPW VKATVGPITN RFLPEDLKQK EFPPAMKLLY SVEHEKPLYL
SFGRPENKRI FPFPIRETSR HFADLAHNSD RNFLRDSSEV SLTGSDA
