ID   CXL16_BOVIN             Reviewed;         252 AA.
AC   Q29RT9;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=C-X-C motif chemokine 16;
DE   AltName: Full=Transmembrane chemokine CXCL16;
DE   Flags: Precursor;
GN   Name=CXCL16;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Induces a strong chemotactic response. Induces calcium
CC       mobilization. Binds to CXCR6/Bonzo. Also acts as a scavenger receptor
CC       on macrophages, which specifically binds to OxLDL (oxidized low density
CC       lipoprotein), suggesting that it may be involved in pathophysiology
CC       such as atherogenesis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- PTM: Glycosylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC       {ECO:0000305}.
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DR   EMBL; BC114022; AAI14023.1; -; mRNA.
DR   RefSeq; NP_001039560.1; NM_001046095.2.
DR   AlphaFoldDB; Q29RT9; -.
DR   STRING; 9913.ENSBTAP00000024371; -.
DR   PaxDb; Q29RT9; -.
DR   Ensembl; ENSBTAT00000024371; ENSBTAP00000024371; ENSBTAG00000031998.
DR   GeneID; 511671; -.
DR   KEGG; bta:511671; -.
DR   CTD; 58191; -.
DR   VEuPathDB; HostDB:ENSBTAG00000031998; -.
DR   VGNC; VGNC:27851; CXCL16.
DR   eggNOG; ENOG502T0B7; Eukaryota.
DR   GeneTree; ENSGT00390000002148; -.
DR   HOGENOM; CLU_049889_0_0_1; -.
DR   InParanoid; Q29RT9; -.
DR   OMA; CPRYIRF; -.
DR   OrthoDB; 1450357at2759; -.
DR   TreeFam; TF337941; -.
DR   Reactome; R-BTA-380108; Chemokine receptors bind chemokines.
DR   Reactome; R-BTA-418594; G alpha (i) signalling events.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000031998; Expressed in lung and 102 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR   GO; GO:0005041; F:low-density lipoprotein particle receptor activity; IBA:GO_Central.
DR   GO; GO:0005044; F:scavenger receptor activity; IBA:GO_Central.
DR   GO; GO:0030307; P:positive regulation of cell growth; IEA:InterPro.
DR   GO; GO:0030335; P:positive regulation of cell migration; IBA:GO_Central.
DR   GO; GO:0006898; P:receptor-mediated endocytosis; IEA:InterPro.
DR   GO; GO:0034341; P:response to interferon-gamma; IEA:InterPro.
DR   GO; GO:0034612; P:response to tumor necrosis factor; IEA:InterPro.
DR   GO; GO:0010818; P:T cell chemotaxis; IBA:GO_Central.
DR   InterPro; IPR026296; CXCL16.
DR   PANTHER; PTHR14385; PTHR14385; 1.
PE   2: Evidence at transcript level;
KW   Chemotaxis; Cytokine; Disulfide bond; Glycoprotein; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..252
FT                   /note="C-X-C motif chemokine 16"
FT                   /id="PRO_0000378191"
FT   TOPO_DOM        26..198
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        220..252
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          115..145
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          163..195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..145
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        34..64
FT                   /evidence="ECO:0000250"
FT   DISULFID        36..78
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   252 AA;  27586 MW;  D72F4536317A6ED4 CRC64;
     MMLGRTSRLL LVLLFIAYAT TSGNGNEGSK VGSCPCDHTV SSHSPPNENI MRHLRKYLKA
     YQRCFSYVRF QLPLKNVCGG STDGWVQELM HCFDSGECGH AQPRVVDAPL HRTQLPEPTE
     AAPSDTATTS QTYLPSTLQR TQQPTPLEGA LSLDSKLIPT HETTTYTSGH SLGAEPEAKE
     NQKQLKENRG PQAGTSATVP VLSLLAIVFI LAGVLLYVVC KRRKNQLLQH PPDLAASLYT
     CSRRTRAENG TL