CXL16_RAT
ID CXL16_RAT Reviewed; 247 AA.
AC Q6AXU5;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=C-X-C motif chemokine 16;
DE AltName: Full=Small-inducible cytokine B16;
DE AltName: Full=Transmembrane chemokine CXCL16;
DE Flags: Precursor;
GN Name=Cxcl16;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
RC STRAIN=Wistar Kyoto; TISSUE=Aortic smooth muscle;
RX PubMed=15890643; DOI=10.1074/jbc.m502586200;
RA Chandrasekar B., Mummidi S., Valente A.J., Patel D.N., Bailey S.R.,
RA Freeman G.L., Hatano M., Tokuhisa T., Jensen L.E.;
RT "The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in
RT rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated
RT kinase, tumor necrosis factor receptor-associated factor 6, c-Src,
RT phosphatidylinositol 3-kinase, Akt, c-Jun N-terminal kinase, and activator
RT protein-1 signaling.";
RL J. Biol. Chem. 280:26263-26277(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Induces a strong chemotactic response. Induces calcium
CC mobilization. Binds to CXCR6/Bonzo. Also acts as a scavenger receptor
CC on macrophages, which specifically binds to OxLDL (oxidized low density
CC lipoprotein), suggesting that it may be involved in pathophysiology
CC such as atherogenesis (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- INDUCTION: By interleukin-18 and the induction is strongly mediated by
CC an activator protein-1-dependent pathway.
CC {ECO:0000269|PubMed:15890643}.
CC -!- PTM: Glycosylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC {ECO:0000305}.
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DR EMBL; DQ025528; AAY42602.1; -; mRNA.
DR EMBL; CH473948; EDM05007.1; -; Genomic_DNA.
DR EMBL; CH473948; EDM05009.1; -; Genomic_DNA.
DR EMBL; BC079312; AAH79312.1; -; mRNA.
DR RefSeq; NP_001017478.1; NM_001017478.1.
DR AlphaFoldDB; Q6AXU5; -.
DR STRING; 10116.ENSRNOP00000037160; -.
DR PaxDb; Q6AXU5; -.
DR Ensembl; ENSRNOT00000032926; ENSRNOP00000037160; ENSRNOG00000026647.
DR GeneID; 497942; -.
DR KEGG; rno:497942; -.
DR UCSC; RGD:1562928; rat.
DR CTD; 58191; -.
DR RGD; 1562928; Cxcl16.
DR eggNOG; ENOG502T0B7; Eukaryota.
DR GeneTree; ENSGT00390000002148; -.
DR HOGENOM; CLU_049889_0_0_1; -.
DR InParanoid; Q6AXU5; -.
DR OMA; CPRYIRF; -.
DR OrthoDB; 1450357at2759; -.
DR PhylomeDB; Q6AXU5; -.
DR TreeFam; TF337941; -.
DR Reactome; R-RNO-380108; Chemokine receptors bind chemokines.
DR Reactome; R-RNO-418594; G alpha (i) signalling events.
DR PRO; PR:Q6AXU5; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Proteomes; UP000234681; Chromosome 10.
DR Bgee; ENSRNOG00000026647; Expressed in adult mammalian kidney and 19 other tissues.
DR Genevisible; Q6AXU5; RN.
DR GO; GO:0005615; C:extracellular space; ISO:RGD.
DR GO; GO:0016021; C:integral component of membrane; ISO:RGD.
DR GO; GO:0008009; F:chemokine activity; ISO:RGD.
DR GO; GO:0042379; F:chemokine receptor binding; ISO:RGD.
DR GO; GO:0005041; F:low-density lipoprotein particle receptor activity; ISO:RGD.
DR GO; GO:0005044; F:scavenger receptor activity; ISO:RGD.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; ISO:RGD.
DR GO; GO:0030307; P:positive regulation of cell growth; ISO:RGD.
DR GO; GO:0030335; P:positive regulation of cell migration; ISO:RGD.
DR GO; GO:0006898; P:receptor-mediated endocytosis; IEA:InterPro.
DR GO; GO:0034097; P:response to cytokine; ISO:RGD.
DR GO; GO:0034341; P:response to interferon-gamma; ISO:RGD.
DR GO; GO:0034612; P:response to tumor necrosis factor; ISO:RGD.
DR GO; GO:0010818; P:T cell chemotaxis; ISO:RGD.
DR InterPro; IPR026296; CXCL16.
DR PANTHER; PTHR14385; PTHR14385; 1.
PE 2: Evidence at transcript level;
KW Chemotaxis; Cytokine; Disulfide bond; Glycoprotein; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..247
FT /note="C-X-C motif chemokine 16"
FT /id="PRO_0000378193"
FT TOPO_DOM 27..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..247
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 120..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 35..65
FT /evidence="ECO:0000250"
FT DISULFID 37..79
FT /evidence="ECO:0000250"
SQ SEQUENCE 247 AA; 27196 MW; EBD43D23E75C7912 CRC64;
MRRGFGPLAL TLFLFFFALL TLPGDGNQGS VAGSCYCDRT IPSGTQIPPA TLNHMRKYLK
TFHRCQFFIR FQLQSKSVCG GSQDQWVREL VNCFEHKQCG IGHGQSFHHQ KHVPQASTRI
PEATEGKPPD TSTAVQFQST QQSTFPSGAP SLNKELTRHW ETTILPSGYG LEARPVAEAN
EKQHKQQKEP GAGAGTQALV PVLSLLAIVF FLVAAMVCVL CNRRVTRQSS SGLQLCYTPV
EPRPQGL
