ID   CXL17_BOVIN             Reviewed;         118 AA.
AC   A4IFR0;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=C-X-C motif chemokine 17;
DE   AltName: Full=VEGF coregulated chemokine 1;
DE   Flags: Precursor;
GN   Name=CXCL17; Synonyms=VCC1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal lung;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Chemokine that acts as chemoattractant for monocytes,
CC       macrophages and dendritic cells. Plays a role in angiogenesis and
CC       possibly in the development of tumors. Acts as an anti-inflammatory in
CC       the stomach. May play a role in the innate defense against infections.
CC       Activates the C-X-C chemokine receptor GPR35 to induce a rapid and
CC       transient rise in the level of intracellular calcium ions.
CC       {ECO:0000250|UniProtKB:Q6UXB2}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q6UXB2}.
CC   -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC134719; AAI34720.1; -; mRNA.
DR   RefSeq; NP_001077268.1; NM_001083799.2.
DR   AlphaFoldDB; A4IFR0; -.
DR   STRING; 9913.ENSBTAP00000024820; -.
DR   PaxDb; A4IFR0; -.
DR   PRIDE; A4IFR0; -.
DR   Ensembl; ENSBTAT00000024820; ENSBTAP00000024820; ENSBTAG00000018652.
DR   GeneID; 788717; -.
DR   KEGG; bta:788717; -.
DR   CTD; 284340; -.
DR   VEuPathDB; HostDB:ENSBTAG00000018652; -.
DR   VGNC; VGNC:27852; CXCL17.
DR   eggNOG; ENOG502TDC2; Eukaryota.
DR   GeneTree; ENSGT00390000002861; -.
DR   HOGENOM; CLU_166962_0_0_1; -.
DR   InParanoid; A4IFR0; -.
DR   OMA; KRCQLAS; -.
DR   OrthoDB; 1577529at2759; -.
DR   TreeFam; TF342477; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000018652; Expressed in abomasum and 59 other tissues.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0048246; P:macrophage chemotaxis; IBA:GO_Central.
DR   GO; GO:0050728; P:negative regulation of inflammatory response; ISS:UniProtKB.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
DR   GO; GO:0010759; P:positive regulation of macrophage chemotaxis; ISS:UniProtKB.
DR   GO; GO:0090026; P:positive regulation of monocyte chemotaxis; ISS:UniProtKB.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; ISS:UniProtKB.
DR   InterPro; IPR029183; CXCL17.
DR   PANTHER; PTHR37351; PTHR37351; 1.
DR   Pfam; PF15211; CXCL17; 1.
PE   3: Inferred from homology;
KW   Angiogenesis; Chemotaxis; Developmental protein; Differentiation;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..118
FT                   /note="C-X-C motif chemokine 17"
FT                   /id="PRO_0000311096"
FT   DISULFID        74..102
FT                   /evidence="ECO:0000305"
FT   DISULFID        76..109
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   118 AA;  13597 MW;  C1A3AE517184191E CRC64;
     MKVLISSLLL LLPLMLMSVV SSSSHTGVAR GQRDQRQASG RWLREGGQEC ECQDWFLRAP
     RRTLMAAPRL TKPCPCDHFK GRMKKTRHQR HHRKSNKPSR ACQQFLTRCL LESFALPL