CXL17_MOUSE
ID CXL17_MOUSE Reviewed; 119 AA.
AC Q5UW37;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=C-X-C motif chemokine 17;
DE Short=6-Cys CXCL17;
DE AltName: Full=13.6 kDa protein;
DE AltName: Full=VEGF coregulated chemokine 1;
DE Contains:
DE RecName: Full=4-Cys CXCL17;
DE Flags: Precursor;
GN Name=Cxcl17; Synonyms=Vcc1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Embryo;
RX PubMed=16989774; DOI=10.1016/j.bbrc.2006.08.194;
RA Weinstein E.J., Head R., Griggs D.W., Sun D., Evans R.J., Swearingen M.L.,
RA Westlin M.M., Mazzarella R.;
RT "VCC-1, a novel chemokine, promotes tumor growth.";
RL Biochem. Biophys. Res. Commun. 350:74-81(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Liver;
RA Nazarian R., Dell'Angelica E.C.;
RT "13.6-kDa protein expressed in liver.";
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=24973458; DOI=10.4049/jimmunol.1400551;
RA Burkhardt A.M., Maravillas-Montero J.L., Carnevale C.D.,
RA Vilches-Cisneros N., Flores J.P., Hevezi P.A., Zlotnik A.;
RT "CXCL17 is a major chemotactic factor for lung macrophages.";
RL J. Immunol. 193:1468-1474(2014).
CC -!- FUNCTION: Chemokine that acts as chemoattractant for monocytes,
CC macrophages and dendritic cells (PubMed:24973458). Plays a role in
CC angiogenesis and possibly in the development of tumors
CC (PubMed:16989774). Acts as an anti-inflammatory in the stomach. May
CC play a role in the innate defense against infections. Activates the C-
CC X-C chemokine receptor GPR35 to induce a rapid and transient rise in
CC the level of intracellular calcium ions. {ECO:0000250|UniProtKB:Q6UXB2,
CC ECO:0000269|PubMed:16989774, ECO:0000269|PubMed:24973458}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q6UXB2}.
CC -!- TISSUE SPECIFICITY: Detected in lung, trachea, lung, tongue thyroid,
CC submaxillary gland, epididymis, and uterus tissues and at a lower level
CC in ovary, prostate and in intestinal tissues.
CC {ECO:0000269|PubMed:16989774, ECO:0000269|PubMed:24973458}.
CC -!- PTM: Likely to undergo an endoproteolytic process to form a four-
CC cysteine-containing mature peptide with a canonical CXC chemokine
CC scaffold after secretion. {ECO:0000250|UniProtKB:D4A875}.
CC -!- DISRUPTION PHENOTYPE: Mice show no defects in breeding or gross anatomy
CC development, and they gained weight normally but exhibit a paucity of
CC macrophages in the lungs (PubMed:24973458).
CC {ECO:0000269|PubMed:24973458}.
CC -!- MISCELLANEOUS: All the mice injected with NIH3T3 cells over-expressing
CC Cxcl17 develop rapidly progressing tumors within 21 days.
CC -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC {ECO:0000305}.
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DR EMBL; AY598463; AAU04874.1; -; mRNA.
DR EMBL; AY374329; AAQ73473.1; -; mRNA.
DR CCDS; CCDS80680.1; -.
DR RefSeq; NP_705804.2; NM_153576.2.
DR AlphaFoldDB; Q5UW37; -.
DR STRING; 10090.ENSMUSP00000073687; -.
DR MaxQB; Q5UW37; -.
DR PaxDb; Q5UW37; -.
DR PRIDE; Q5UW37; -.
DR ProteomicsDB; 279247; -.
DR Antibodypedia; 66724; 97 antibodies from 18 providers.
DR Ensembl; ENSMUST00000200880; ENSMUSP00000144096; ENSMUSG00000060188.
DR GeneID; 232983; -.
DR KEGG; mmu:232983; -.
DR UCSC; uc009fst.1; mouse.
DR CTD; 284340; -.
DR MGI; MGI:2387642; Cxcl17.
DR VEuPathDB; HostDB:ENSMUSG00000060188; -.
DR eggNOG; ENOG502TDC2; Eukaryota.
DR GeneTree; ENSGT00390000002861; -.
DR HOGENOM; CLU_166962_0_0_1; -.
DR InParanoid; Q5UW37; -.
DR OMA; KRCQLAS; -.
DR OrthoDB; 1577529at2759; -.
DR PhylomeDB; Q5UW37; -.
DR BioGRID-ORCS; 232983; 1 hit in 33 CRISPR screens.
DR ChiTaRS; Cxcl17; mouse.
DR PRO; PR:Q5UW37; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q5UW37; protein.
DR Bgee; ENSMUSG00000060188; Expressed in submandibular gland and 44 other tissues.
DR ExpressionAtlas; Q5UW37; baseline and differential.
DR Genevisible; Q5UW37; MM.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0008009; F:chemokine activity; ISO:MGI.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; ISO:MGI.
DR GO; GO:0048246; P:macrophage chemotaxis; IMP:MGI.
DR GO; GO:0050728; P:negative regulation of inflammatory response; ISS:UniProtKB.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:MGI.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
DR GO; GO:0010759; P:positive regulation of macrophage chemotaxis; IMP:UniProtKB.
DR GO; GO:0090026; P:positive regulation of monocyte chemotaxis; ISS:UniProtKB.
DR GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; ISS:UniProtKB.
DR InterPro; IPR029183; CXCL17.
DR PANTHER; PTHR37351; PTHR37351; 1.
DR Pfam; PF15211; CXCL17; 1.
PE 2: Evidence at transcript level;
KW Angiogenesis; Chemotaxis; Cleavage on pair of basic residues;
KW Developmental protein; Differentiation; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..119
FT /note="C-X-C motif chemokine 17"
FT /id="PRO_5000000292"
FT CHAIN 64..119
FT /note="4-Cys CXCL17"
FT /evidence="ECO:0000305"
FT /id="PRO_0000438488"
FT REGION 75..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..99
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 63..64
FT /note="Cleavage"
FT /evidence="ECO:0000250|UniProtKB:D4A875"
FT DISULFID 75..103
FT /evidence="ECO:0000305"
FT DISULFID 77..110
FT /evidence="ECO:0000305"
SQ SEQUENCE 119 AA; 13627 MW; 314BA9416EC40D9E CRC64;
MKLLASPFLL LLPVMLMSMV FSSPNPGVAR SHGDQHLAPR RWLLEGGQEC ECKDWFLQAP
KRKATAVLGP PRKQCPCDHV KGREKKNRHQ KHHRKSQRPS RACQQFLKRC HLASFALPL
