ID   CXL_CONCN               Reviewed;         146 AA.
AC   P0DKQ7;
DT   31-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2012, sequence version 1.
DT   25-MAY-2022, entry version 15.
DE   RecName: Full=Linear conopeptide {ECO:0000303|PubMed:22705119};
DE   Contains:
DE     RecName: Full=Linear conopeptide-Cn1 {ECO:0000303|PubMed:22705119};
DE   Contains:
DE     RecName: Full=Linear conopeptide-Cn2 {ECO:0000303|PubMed:22705119};
DE     AltName: Full=[oxMet6]-Cn2 {ECO:0000303|PubMed:22705119};
DE   Contains:
DE     RecName: Full=Linear conopeptide-Cn3 {ECO:0000303|PubMed:22705119};
DE   Contains:
DE     RecName: Full=Linear conopeptide-Cn4 {ECO:0000303|PubMed:22705119};
DE   Flags: Precursor;
OS   Conus consors (Singed cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Pionoconus.
OX   NCBI_TaxID=101297;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], OXIDATION AT MET-40, MASS SPECTROMETRY,
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=22705119; DOI=10.1016/j.jprot.2012.06.001;
RA   Violette A., Biass D., Dutertre S., Koua D., Piquemal D., Pierrat F.,
RA   Stocklin R., Favreau P.;
RT   "Large-scale discovery of conopeptides and conoproteins in the injectable
RT   venom of a fish-hunting cone snail using a combined proteomic and
RT   transcriptomic approach.";
RL   J. Proteomics 75:5215-5225(2012).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22705119}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:22705119}.
CC   -!- MASS SPECTROMETRY: [Linear conopeptide-Cn2]: Mass=2325.88;
CC       Method=Electrospray; Note=Cn2.; Evidence={ECO:0000269|PubMed:22705119};
CC   -!- MASS SPECTROMETRY: [Linear conopeptide-Cn2]: Mass=2341.90;
CC       Method=Electrospray; Note=[oxMet]-Cn2.;
CC       Evidence={ECO:0000269|PubMed:22705119};
CC   -!- MASS SPECTROMETRY: [Linear conopeptide-Cn1]: Mass=2178.89;
CC       Method=Electrospray; Note=Cn1.; Evidence={ECO:0000269|PubMed:22705119};
CC   -!- MASS SPECTROMETRY: [Linear conopeptide-Cn4]: Mass=2726.09;
CC       Method=Electrospray; Note=Cn4.; Evidence={ECO:0000269|PubMed:22705119};
CC   -!- MASS SPECTROMETRY: [Linear conopeptide-Cn3]: Mass=1970.76;
CC       Method=Electrospray; Note=Cn3.; Evidence={ECO:0000269|PubMed:22705119};
CC   -!- MISCELLANEOUS: Found in injectable (milked) (IV) venom.
CC       {ECO:0000305|PubMed:22705119}.
CC   -!- MISCELLANEOUS: The mature peptide does not contain cysteine residue.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P0DKQ7; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Oxidation; Secreted; Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..34
FT                   /evidence="ECO:0000305|PubMed:22705119"
FT                   /id="PRO_0000419890"
FT   PEPTIDE         35..57
FT                   /note="Linear conopeptide-Cn2"
FT                   /evidence="ECO:0000269|PubMed:22705119"
FT                   /id="PRO_0000419891"
FT   PEPTIDE         36..57
FT                   /note="Linear conopeptide-Cn1"
FT                   /evidence="ECO:0000269|PubMed:22705119"
FT                   /id="PRO_0000419892"
FT   PROPEP          58..80
FT                   /evidence="ECO:0000305|PubMed:22705119"
FT                   /id="PRO_0000419893"
FT   PEPTIDE         81..103
FT                   /note="Linear conopeptide-Cn4"
FT                   /evidence="ECO:0000269|PubMed:22705119"
FT                   /id="PRO_0000419894"
FT   PEPTIDE         87..103
FT                   /note="Linear conopeptide-Cn3"
FT                   /evidence="ECO:0000269|PubMed:22705119"
FT                   /id="PRO_0000419895"
FT   PROPEP          104..146
FT                   /evidence="ECO:0000305|PubMed:22705119"
FT                   /id="PRO_0000419896"
FT   REGION          107..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         40
FT                   /note="Methionine sulfoxide; partial; in Cn2"
FT                   /evidence="ECO:0000269|PubMed:22705119"
SQ   SEQUENCE   146 AA;  16367 MW;  4F50AE6CCEEF597E CRC64;
     MLRLIIAAAV LVSACLAYPQ RREGAPADAA NLQSFDPALM SMQGMQGGQM PGMAGGQFLP
     FNPNLQMGYK RDFDENLEKR KQHSQFNADE NKAPFDSEEN FMNFLHNEKG DKHPFANVDS
     ADTDLGQFEP SAENKNGEFR FFDKEQ