ID   CXPH_CONRA              Reviewed;          84 AA.
AC   P58990;
DT   13-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-2002, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Conophysin-R {ECO:0000303|PubMed:12076643};
OS   Conus radiatus (Rayed cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Phasmoconus.
OX   NCBI_TaxID=61198;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=12076643; DOI=10.1016/s0041-0101(02)00079-x;
RA   Lirazan M., Jimenez E.C., Grey Craig A., Olivera B.M., Cruz L.J.;
RT   "Conophysin-R, a Conus radiatus venom peptide belonging to the neurophysin
RT   family.";
RL   Toxicon 40:901-908(2002).
CC   -!- FUNCTION: Targets vasopressin-oxytocin related receptors (By
CC       similarity). No effect observed when injected into goldfish or into
CC       mice. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12076643}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:12076643}.
CC   -!- MASS SPECTROMETRY: Mass=8808.1; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:12076643};
CC   -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
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DR   AlphaFoldDB; P58990; -.
DR   SMR; P58990; -.
DR   ConoServer; 5810; conophysin-R.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.9.10; -; 1.
DR   InterPro; IPR000981; Neurhyp_horm.
DR   InterPro; IPR036387; Neurhyp_horm_dom_sf.
DR   Pfam; PF00184; Hormone_5; 1.
DR   PRINTS; PR00831; NEUROPHYSIN.
DR   SMART; SM00003; NH; 1.
DR   SUPFAM; SSF49606; SSF49606; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond;
KW   G-protein coupled receptor impairing toxin; Secreted; Toxin.
FT   CHAIN           1..84
FT                   /note="Conophysin-R"
FT                   /evidence="ECO:0000269|PubMed:12076643"
FT                   /id="PRO_0000160940"
FT   DISULFID        6..46
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        9..20
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        14..36
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        21..26
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        53..71
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        65..83
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        72..77
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
SQ   SEQUENCE   84 AA;  8825 MW;  20123ABA7B0FAA08 CRC64;
     HPTKPCMYCS FGQCVGPHIC CGPTGCEMGT AEANMCSEED EDPIPCQVFG SDCALNNPDN
     IHGHCVADGI CCVDDTCTTH LGCL