ID   CXQA_CONRG              Reviewed;          40 AA.
AC   P0DL31;
DT   26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2013, sequence version 1.
DT   25-MAY-2022, entry version 17.
DE   RecName: Full=Omega-conotoxin RsXXVIA {ECO:0000305};
DE   AltName: Full=RsXXIVA {ECO:0000303|PubMed:23567319};
OS   Conus regularis (Regular cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Dauciconus.
OX   NCBI_TaxID=1333719;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, BIOASSAY, IDENTIFICATION BY MASS SPECTROMETRY,
RP   AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=23567319; DOI=10.3390/md11041188;
RA   Bernaldez J., Roman-Gonzalez S.A., Martinez O., Jimenez S., Vivas O.,
RA   Arenas I., Corzo G., Arreguin R., Garcia D.E., Possani L.D., Licea A.;
RT   "A Conus regularis conotoxin with a novel eight-cysteine framework inhibits
RT   CaV2.2 channels and displays an anti-nociceptive activity.";
RL   Mar. Drugs 11:1188-1202(2013).
CC   -!- FUNCTION: Omega-conotoxins act at presynaptic membranes, they bind and
CC       block voltage-gated calcium channels (Cav). This toxin inhibits rat
CC       Cav2.2/CACNA1B calcium channels in a dose-dependent manner (EC(50)=2.8
CC       uM), whose effect is partially reversed after washing. In vivo, when
CC       injected into mice, it shows both an analgesic effect in acute thermal
CC       pain at 30 and 45 minutes post-injection and an anti-nociceptive effect
CC       in a formalin chronic pain test. {ECO:0000269|PubMed:23567319}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23567319}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:23567319}.
CC   -!- DOMAIN: The cysteine framework is XXVI (C-C-C-C-CC-CC). {ECO:0000305}.
CC   -!- PTM: Contains 4 disulfide bonds. {ECO:0000305}.
CC   -!- MISCELLANEOUS: The framework of this peptide is described as framework
CC       XXIV but this framework name was already attributed to another cysteine
CC       pattern (see AC J7JU64). The framework is therefore renamed to the
CC       lowest available number, XXVI, and the peptide is consequently renamed
CC       RsXXVIA. {ECO:0000305}.
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DR   AlphaFoldDB; P0DL31; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Calcium channel impairing toxin; Cleavage on pair of basic residues;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Neurotoxin; Secreted; Toxin; Voltage-gated calcium channel impairing toxin.
FT   CHAIN           1..40
FT                   /note="Omega-conotoxin RsXXVIA"
FT                   /evidence="ECO:0000269|PubMed:23567319"
FT                   /id="PRO_0000422884"
SQ   SEQUENCE   40 AA;  4121 MW;  31ACA0207BDA1E74 CRC64;
     CKGQSCSSCS TKEFCLSKGS RLMYDCCTGS CCGVKTAGVT