ID   CXRA_CONMO              Reviewed;          37 AA.
AC   A0A0R4I952;
DT   18-JUL-2018, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2016, sequence version 1.
DT   25-MAY-2022, entry version 19.
DE   RecName: Full=Delta/kappa-conotoxin Mo3964 {ECO:0000305};
DE            Short=Mo3964 {ECO:0000303|PubMed:25961405};
OS   Conus monile (Necklace cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Strategoconus.
OX   NCBI_TaxID=351660;
RN   [1]
RP   STRUCTURE BY NMR, FUNCTION, AND DISULFIDE BONDS.
RX   PubMed=25961405; DOI=10.1021/acschembio.5b00226;
RA   Kancherla A.K., Meesala S., Jorwal P., Palanisamy R., Sikdar S.K.,
RA   Sarma S.P.;
RT   "A disulfide stabilized beta-sandwich defines the structure of a new
RT   cysteine framework M-superfamily conotoxin.";
RL   ACS Chem. Biol. 10:1847-1860(2015).
CC   -!- FUNCTION: This toxin reduces the outward currents that are due to the
CC       opening of voltage-gated potassium channels in DRG neurons. In
CC       addition, leftward shift in the presence of this toxin is observed in
CC       averaged normalized conductance-voltage plot of outward sodium currents
CC       (Nav1.2/SCN2A). {ECO:0000269|PubMed:25961405}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:25961405}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:25961405}.
CC   -!- DOMAIN: The cysteine framework is XXXII (C-CC-C-C-C). {ECO:0000305}.
CC   -!- MISCELLANEOUS: Exists in two forms, due to cis-trans isomerization at
CC       23-Asp-Pro-24. {ECO:0000269|PubMed:25961405}.
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DR   PDB; 2MW7; NMR; -; A=1-37.
DR   PDBsum; 2MW7; -.
DR   AlphaFoldDB; A0A0R4I952; -.
DR   SMR; A0A0R4I952; -.
DR   ConoServer; 7063; Mo3964.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   3D-structure; Disulfide bond; Ion channel impairing toxin;
KW   Potassium channel impairing toxin; Secreted; Toxin;
KW   Voltage-gated potassium channel impairing toxin;
KW   Voltage-gated sodium channel impairing toxin.
FT   CHAIN           1..37
FT                   /note="Delta/kappa-conotoxin Mo3964"
FT                   /evidence="ECO:0000269|PubMed:25961405"
FT                   /id="PRO_0000444692"
FT   DISULFID        4..12
FT                   /evidence="ECO:0000269|PubMed:25961405,
FT                   ECO:0000312|PDB:2MW7"
FT   DISULFID        11..27
FT                   /evidence="ECO:0000269|PubMed:25961405,
FT                   ECO:0000312|PDB:2MW7"
FT   DISULFID        21..34
FT                   /evidence="ECO:0000269|PubMed:25961405,
FT                   ECO:0000312|PDB:2MW7"
FT   TURN            29..31
FT                   /evidence="ECO:0007829|PDB:2MW7"
FT   STRAND          33..35
FT                   /evidence="ECO:0007829|PDB:2MW7"
SQ   SEQUENCE   37 AA;  3970 MW;  011455C0CDF1A35A CRC64;
     DGECGDKDEP CCGRPDGAKV CNDPWVCILT SSRCENP