ID   CXXC4_XENTR             Reviewed;         188 AA.
AC   Q0VFP6;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=CXXC-type zinc finger protein 4;
GN   Name=cxxc4;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a negative regulator of the Wnt signaling pathway
CC       required for anterior neural structure formation (By similarity). Binds
CC       preferentially to DNA containing cytidine-phosphate-guanosine (CpG)
CC       dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and
CC       hemimethylated-hydroxymethyl-CpG (By similarity).
CC       {ECO:0000250|UniProtKB:Q800L6, ECO:0000250|UniProtKB:Q9H2H0}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9EQC9}.
CC   -!- DOMAIN: The CXXC zinc finger mediates binding to CpG-DNA.
CC       {ECO:0000250|UniProtKB:Q9H2H0}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI18751.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC118750; AAI18751.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001072200.2; NM_001078732.2.
DR   AlphaFoldDB; Q0VFP6; -.
DR   SMR; Q0VFP6; -.
DR   DNASU; 779646; -.
DR   GeneID; 779646; -.
DR   KEGG; xtr:779646; -.
DR   CTD; 80319; -.
DR   Xenbase; XB-GENE-479477; cxxc4.
DR   InParanoid; Q0VFP6; -.
DR   OrthoDB; 946583at2759; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0008327; F:methyl-CpG binding; ISS:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; ISS:UniProtKB.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0007352; P:zygotic specification of dorsal/ventral axis; IDA:BHF-UCL.
DR   InterPro; IPR040388; CXXC4/CXXC5.
DR   InterPro; IPR002857; Znf_CXXC.
DR   PANTHER; PTHR13419; PTHR13419; 1.
DR   Pfam; PF02008; zf-CXXC; 1.
DR   PROSITE; PS51058; ZF_CXXC; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; DNA-binding; Metal-binding; Reference proteome;
KW   Wnt signaling pathway; Zinc; Zinc-finger.
FT   CHAIN           1..188
FT                   /note="CXXC-type zinc finger protein 4"
FT                   /id="PRO_0000317546"
FT   ZN_FING         122..163
FT                   /note="CXXC-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00509"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         129
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00509"
FT   BINDING         132
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00509"
FT   BINDING         135
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00509"
FT   BINDING         141
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00509"
FT   BINDING         144
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00509"
FT   BINDING         147
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00509"
FT   BINDING         157
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00509"
FT   BINDING         162
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00509"
SQ   SEQUENCE   188 AA;  20037 MW;  28E8F36DECF2A7F8 CRC64;
     MHRNDSQRLG KPGGAPESLQ MANNNFLSTL SPEHCRPLAG ECMNKLKCGA AEAEIMNLPE
     RVGTFSAIPA LGGISLPPGV IVMTALHSPA AASAAVTDSA FQIANLADCP QNNSSGAGGN
     PAKKKRKRCG VCVPCKRLIN CGVCSSCRNR KTGHQICKFR KCEELKKKPG TSLERTPVPS
     AEAFRWFF