CXXS2_ARATH
ID CXXS2_ARATH Reviewed; 154 AA.
AC Q8GXV2; Q38878;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Thioredoxin-like protein CXXS2;
DE Short=AtCXXS2;
DE AltName: Full=Mono-cysteine thioredoxin 2;
GN Name=CXXS2; OrderedLocusNames=At2g40790; ORFNames=T7D17.3;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=8642611; DOI=10.1007/bf02498636;
RA Sahrawy M., Hecht V., Lopez Jaramillo J., Chueca A., Chartier Y., Meyer Y.;
RT "Intron position as an evolutionary marker of thioredoxins and thioredoxin
RT domains.";
RL J. Mol. Evol. 42:422-431(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=18384502; DOI=10.1111/j.1399-3054.2008.01093.x;
RA Serrato A.J., Guilleminot J., Meyer Y., Vignols F.;
RT "AtCXXS: atypical members of the Arabidopsis thaliana thioredoxin h family
RT with a remarkably high disulfide isomerase activity.";
RL Physiol. Plantarum 133:611-622(2008).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19825616; DOI=10.1093/mp/ssn076;
RA Chibani K., Wingsle G., Jacquot J.P., Gelhaye E., Rouhier N.;
RT "Comparative genomic study of the thioredoxin family in photosynthetic
RT organisms with emphasis on Populus trichocarpa.";
RL Mol. Plant 2:308-322(2009).
CC -!- FUNCTION: Possesses low disulfide reductase activity, but efficient
CC protein disulfide isomerase activity. Does not possess
CC deglutathionylation activity. {ECO:0000269|PubMed:18384502}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18384502}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:18384502}.
CC -!- SIMILARITY: Belongs to the thioredoxin family. {ECO:0000305}.
CC -!- CAUTION: Lacks the conserved cysteine (here Ser-77), present in the
CC redox-active center, which is one of the conserved features of the
CC thioredoxin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC49350.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; U35639; AAC49350.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC09879.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM62990.1; -; Genomic_DNA.
DR EMBL; AK118023; BAC42656.1; -; mRNA.
DR EMBL; BT003671; AAO39899.1; -; mRNA.
DR PIR; H84833; H84833.
DR RefSeq; NP_001318396.1; NM_001336864.1.
DR RefSeq; NP_181611.2; NM_129642.4.
DR AlphaFoldDB; Q8GXV2; -.
DR SMR; Q8GXV2; -.
DR STRING; 3702.AT2G40790.1; -.
DR PaxDb; Q8GXV2; -.
DR PRIDE; Q8GXV2; -.
DR EnsemblPlants; AT2G40790.1; AT2G40790.1; AT2G40790.
DR EnsemblPlants; AT2G40790.2; AT2G40790.2; AT2G40790.
DR GeneID; 818676; -.
DR Gramene; AT2G40790.1; AT2G40790.1; AT2G40790.
DR Gramene; AT2G40790.2; AT2G40790.2; AT2G40790.
DR KEGG; ath:AT2G40790; -.
DR Araport; AT2G40790; -.
DR TAIR; locus:2064854; AT2G40790.
DR eggNOG; KOG0907; Eukaryota.
DR HOGENOM; CLU_090389_14_1_1; -.
DR InParanoid; Q8GXV2; -.
DR OMA; CTRIPCC; -.
DR OrthoDB; 1482186at2759; -.
DR PhylomeDB; Q8GXV2; -.
DR PRO; PR:Q8GXV2; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q8GXV2; baseline and differential.
DR Genevisible; Q8GXV2; AT.
DR GO; GO:0005829; C:cytosol; IDA:TAIR.
DR GO; GO:0003756; F:protein disulfide isomerase activity; IDA:TAIR.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR Pfam; PF00085; Thioredoxin; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Isomerase; Phosphoprotein; Reference proteome.
FT CHAIN 1..154
FT /note="Thioredoxin-like protein CXXS2"
FT /id="PRO_0000394547"
FT DOMAIN 23..148
FT /note="Thioredoxin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
FT MOD_RES 31
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C9Y6"
SQ SEQUENCE 154 AA; 17314 MW; A9B0DB455E890401 CRC64;
MGNHCTRIPC CKKVCSCICC CNRRNKTQAR SQKGSYFIKG KVHPVSRMEK WEEKITEANS
HGKILVVNFK ASWCLPSKTI LPIYQELAST YTSMIFVTID VEELAEFSHE WNVDATPTVV
FLKDGRQMDK LVGGDAAELQ KKTAAAANLL LRQS
