ID   CXY17_CONCB             Reviewed;          74 AA.
AC   B4YSU8;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Conotoxin ca17a {ECO:0000305};
DE   AltName: Full=Conotoxin ca16a {ECO:0000303|PubMed:18584917};
DE   Flags: Precursor;
OS   Conus caracteristicus (Characteristic cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus.
OX   NCBI_TaxID=89440;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 41-74, MASS SPECTROMETRY,
RP   HYDROXYLATION AT PRO-51, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=18584917; DOI=10.1016/j.peptides.2008.05.015;
RA   Yuan D.-D., Liu L., Shao X.-X., Peng C., Chi C.-W., Guo Z.-Y.;
RT   "Isolation and cloning of a conotoxin with a novel cysteine pattern from
RT   Conus caracteristicus.";
RL   Peptides 29:1521-1525(2008).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18584917}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- DOMAIN: The cysteine framework is XVII (C-C-CC-C-CC-C).
CC   -!- PTM: Contains disulfide bonds. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=3517.6; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:18584917};
CC   -!- SIMILARITY: Belongs to the conotoxin Y superfamily. {ECO:0000305}.
CC   -!- CAUTION: The authors initially published the new framework as framework
CC       XVI which was already attributed to another cysteine pattern (AC
CC       Q2I2P8). In order to be consistent with the current nomenclature rules
CC       and with the new reassignment proposed by ConoServer, we now designate
CC       this cysteine pattern as XVII. We also follow ConoServer for assigning
CC       this toxin to the conotoxin Y superfamily.
CC       {ECO:0000305|PubMed:18584917}.
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DR   EMBL; EU675847; ACF93417.1; -; mRNA.
DR   AlphaFoldDB; B4YSU8; -.
DR   SMR; B4YSU8; -.
DR   ConoServer; 2839; CaXVIIA precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hydroxylation; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..40
FT                   /evidence="ECO:0000269|PubMed:18584917"
FT                   /id="PRO_0000397119"
FT   PEPTIDE         41..74
FT                   /note="Conotoxin ca17a"
FT                   /evidence="ECO:0000269|PubMed:18584917"
FT                   /id="PRO_0000397120"
FT   MOD_RES         51
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000269|PubMed:18584917"
SQ   SEQUENCE   74 AA;  7786 MW;  98F853C47663D15F CRC64;
     MQKATVLLLA LLLLLPLSTA QDAEGSQEDA AQREVDIATR CGGTGDSCNE PAGELCCRRL
     KCVNSRCCPT TDGC