ID   CY075_POSPM             Reviewed;         613 AA.
AC   F1SY74;
DT   02-DEC-2020, integrated into UniProtKB/Swiss-Prot.
DT   31-MAY-2011, sequence version 1.
DT   03-AUG-2022, entry version 26.
DE   RecName: Full=Cytochrome P450 monooxygenase 75 {ECO:0000303|PubMed:21938516};
DE            EC=1.-.-.- {ECO:0000269|PubMed:21938516};
GN   Name=CYP075 {ECO:0000303|PubMed:21938516};
GN   Synonyms=CYP63A6v1 {ECO:0000303|PubMed:21938516};
OS   Postia placenta (strain ATCC 44394 / Madison 698-R) (Brown rot fungus)
OS   (Poria monticola).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Polyporales; Dacryobolaceae; Postia.
OX   NCBI_TaxID=561896;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION, FUNCTION, AND CATALYTIC
RP   ACTIVITY.
RC   STRAIN=ATCC 44394 / Madison 698-R;
RX   PubMed=21938516; DOI=10.1007/s00203-011-0753-2;
RA   Ide M., Ichinose H., Wariishi H.;
RT   "Molecular identification and functional characterization of cytochrome
RT   P450 monooxygenases from the brown-rot basidiomycete Postia placenta.";
RL   Arch. Microbiol. 194:243-253(2012).
CC   -!- FUNCTION: Cytochrome P450 monooxygenase that is able to use carbazole
CC       and 3,5,4'-trimethoxy-trans-stilbene as substrates for oxidation.
CC       {ECO:0000269|PubMed:21938516}.
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413;
CC         Evidence={ECO:0000250|UniProtKB:P04798};
CC   -!- PATHWAY: Secondary metabolite biosynthesis. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; AB573285; BAK09418.1; -; mRNA.
DR   AlphaFoldDB; F1SY74; -.
DR   SMR; F1SY74; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   1: Evidence at protein level;
KW   Glycoprotein; Heme; Iron; Membrane; Metal-binding; Monooxygenase;
KW   Oxidoreductase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..613
FT                   /note="Cytochrome P450 monooxygenase 75"
FT                   /id="PRO_0000451372"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         526
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250|UniProtKB:P04798"
FT   CARBOHYD        434
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   613 AA;  69844 MW;  7C91E3589D99FF73 CRC64;
     MALPPGVPFL IRVSLILAFA PVCVVIVANF IWRHTDVALP TWPVTLLSVA STPLTILVRV
     WYRQWKYQRA AARLGAIMPP RWVGKKLGNL DILKEMLQTM QSGYIADFAW KLFNNLGNTV
     QMNVLGGTAY LTCDPNIIKS VLATDFNNFE KGDLFKQEMA SVLGTGVFNA DGDMWKWHRA
     MTRPFFSRDR ISHFELFDRR SEQAVAKMTE RFHSGYAVDF QDLISRFTLD SATEFLFGSC
     VNSLHSPLPY PHNQHPTPFS HPSSKSLASN PSRAEAVASA FMRAQIVLAE RVAMGAIWPL
     LEMRKSRTGE HMRIIDEYLD PILKDALRRK EDMANIGAGI HDDKESSDTD GETLLDHLVR
     LTSDPVVLHD EVLNILIAGR DTTAGTLTFV VYFLCMYPDV FNRLRAEVLE KVGPNARPTY
     ADIKEMRYLR AVINETLRLY PVVPFNIRWS IHEGTLPNPD PNGKPFYLPP KTPVTYTVFA
     MHRRKEYWGP DADEFDPDRF LDDRVAKYLT KNPFIFLPFN AGPRICLGQQ FAYNEMSFFL
     IKLMQHFSAM ELAPEAAPPE SLPPAEWAVT GWGRKRIERF WPKSHLTLYS NGGMWVKMVE
     ADDFDKDDRD VGI