ID   CY079_POSPM             Reviewed;         567 AA.
AC   F1SY75;
DT   02-DEC-2020, integrated into UniProtKB/Swiss-Prot.
DT   31-MAY-2011, sequence version 1.
DT   03-AUG-2022, entry version 26.
DE   RecName: Full=Cytochrome P450 monooxygenase 79 {ECO:0000303|PubMed:21938516};
DE            EC=1.-.-.- {ECO:0000269|PubMed:21938516};
GN   Name=CYP079 {ECO:0000303|PubMed:21938516};
GN   Synonyms=CYP5027B4v1 {ECO:0000303|PubMed:21938516};
OS   Postia placenta (strain ATCC 44394 / Madison 698-R) (Brown rot fungus)
OS   (Poria monticola).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Polyporales; Dacryobolaceae; Postia.
OX   NCBI_TaxID=561896;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION, FUNCTION, AND CATALYTIC
RP   ACTIVITY.
RC   STRAIN=ATCC 44394 / Madison 698-R;
RX   PubMed=21938516; DOI=10.1007/s00203-011-0753-2;
RA   Ide M., Ichinose H., Wariishi H.;
RT   "Molecular identification and functional characterization of cytochrome
RT   P450 monooxygenases from the brown-rot basidiomycete Postia placenta.";
RL   Arch. Microbiol. 194:243-253(2012).
CC   -!- FUNCTION: Cytochrome P450 monooxygenase that is able to use
CC       dehydroabietic acid as a substrate for oxidation.
CC       {ECO:0000269|PubMed:21938516}.
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413;
CC         Evidence={ECO:0000250|UniProtKB:P04798};
CC   -!- PATHWAY: Secondary metabolite biosynthesis. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; AB573286; BAK09419.1; -; mRNA.
DR   AlphaFoldDB; F1SY75; -.
DR   SMR; F1SY75; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
PE   1: Evidence at protein level;
KW   Glycoprotein; Heme; Iron; Membrane; Metal-binding; Monooxygenase;
KW   Oxidoreductase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..567
FT                   /note="Cytochrome P450 monooxygenase 79"
FT                   /id="PRO_0000451363"
FT   TRANSMEM        7..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         475
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250|UniProtKB:P04798"
FT   CARBOHYD        223
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        279
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   567 AA;  64219 MW;  FE264203051B4098 CRC64;
     MAVSTNELAI LAIVLLVTAV VFYTKGTRRA PLPPGPRGIP FLGNLFQFNV MRPYPQYLKW
     AQKYGPVFSI KLGSQRIIVL STSEAADELF VTRSKLYSSH ESPHVGFDLV SDQQRMVFMP
     YSREWKIVRK NVHGILGPGP SKQMRKMQDL ECRIMLHDLL CHGDTSIVED FVEGPHGKVP
     ERHWFSIIRR YTTSLMMTLV YGRRIHRIVD NPELHQVYEM MSNMTHVSQP GRYLVDALPI
     LRWLPDIMAP WRAEGKRMHE WEMGFWGKLF ADSRTAFLNG TGLNGFVQSY LSARAEAGLE
     DLPGKGATED GAGWMRDKLI TYTAVSIIEA GSDTTSTAVF SFVLLMLSNP DALRRAKEEM
     GAVVGSSRMP DWEDEDRLPW LTACIKETLR CAPPLPLGIP HKADEDDVYN GYLIPKGSTV
     IGNIWAIHMD PVRYPDPTAF KPERFYNPDG KLNWASGPDT HNRDHYIFGW GRRFCSGKYL
     AEASMFIVLS RLIWGFDFYA ASDPQTGKVK LPDVNDVDTF TDGLVTAPKI YPVGFKPRSE
     KHAEMIKASY RDVQNDWQSM GLAGDER