ID   CY110_POSPM             Reviewed;         498 AA.
AC   F1SY99;
DT   02-DEC-2020, integrated into UniProtKB/Swiss-Prot.
DT   31-MAY-2011, sequence version 1.
DT   03-AUG-2022, entry version 23.
DE   RecName: Full=Cytochrome P450 monooxygenase 110 {ECO:0000303|PubMed:21938516};
DE            EC=1.-.-.- {ECO:0000269|PubMed:21938516};
GN   Name=CYP110 {ECO:0000303|PubMed:21938516};
GN   Synonyms=CYP512N6v2 {ECO:0000303|PubMed:21938516};
OS   Postia placenta (strain ATCC 44394 / Madison 698-R) (Brown rot fungus)
OS   (Poria monticola).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Polyporales; Dacryobolaceae; Postia.
OX   NCBI_TaxID=561896;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION, FUNCTION, AND CATALYTIC
RP   ACTIVITY.
RC   STRAIN=ATCC 44394 / Madison 698-R;
RX   PubMed=21938516; DOI=10.1007/s00203-011-0753-2;
RA   Ide M., Ichinose H., Wariishi H.;
RT   "Molecular identification and functional characterization of cytochrome
RT   P450 monooxygenases from the brown-rot basidiomycete Postia placenta.";
RL   Arch. Microbiol. 194:243-253(2012).
CC   -!- FUNCTION: Cytochrome P450 monooxygenase that is able to use
CC       dehydroabietic acid and testosterone as substrates for oxidation,
CC       suggesting that the natural substrate(s) may be structurally related to
CC       steroid compounds. {ECO:0000269|PubMed:21938516}.
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413;
CC         Evidence={ECO:0000250|UniProtKB:P04798};
CC   -!- PATHWAY: Secondary metabolite biosynthesis. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; AB573310; BAK09443.1; -; mRNA.
DR   AlphaFoldDB; F1SY99; -.
DR   SMR; F1SY99; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   1: Evidence at protein level;
KW   Glycoprotein; Heme; Iron; Membrane; Metal-binding; Monooxygenase;
KW   Oxidoreductase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..498
FT                   /note="Cytochrome P450 monooxygenase 110"
FT                   /id="PRO_0000451361"
FT   TRANSMEM        7..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         440
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250|UniProtKB:P04798"
FT   CARBOHYD        425
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   498 AA;  56594 MW;  568B69F3CB5FEF49 CRC64;
     MEDKAQYVFA LLGILATLYF VRWSTDPLRH IPAIGPSAPI VSYLSAYRYC RNAQSILQEG
     YHKYKVFRVS LVDRWVVVVS GADMNEELRK VPDTHVSFQE AADDLIQLKY TIAPDVNEHP
     IHTPVIRGPL TRNLGALFPD VVDEINVAFP ELMPPAAKRG DWVAVSVRDT MGRIVSRASN
     RIFVGLPLCR NPDYLKTVVE FAFSVAKSRT IINAAPAVFR PIVGHFLPWA KRAVRNAGVH
     VKPLIRLRVS KMQDAGDDQT DKSCDYLMWL IEEAQKTKQN LDIVVQGILV SNFAAIHTSS
     NSITHSLLNL AAYPQHVQPL REEIEGIIKE YGWTKEAIGK MWKLDSFMRE SQRLSGISGI
     SVMRKVLQDI TLSDGTYLPK GTLVVAAAFA THTDERYYEN PEVFEPFRFY DMRTENDALR
     KQYVNTSREF ITFGHGKHAC PGRFFAVNEL KAMMAYIILH YDVKLEEGVS RPENVWIWHN
     ISPASTKVLF RERQSKVQ