ID   CY553_HELPY             Reviewed;          96 AA.
AC   O25825;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Cytochrome c-553;
DE   AltName: Full=Cytochrome c553;
DE   Flags: Precursor;
GN   OrderedLocusNames=HP_1227;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
RN   [2]
RP   PROTEIN SEQUENCE OF 20-28, AND CHARACTERIZATION.
RX   PubMed=10965034; DOI=10.1093/oxfordjournals.jbchem.a022763;
RA   Koyanagi S., Nagata K., Tamura T., Tsukita S., Sone N.;
RT   "Purification and characterization of cytochrome c-553 from Helicobacter
RT   pylori.";
RL   J. Biochem. 128:371-375(2000).
CC   -!- FUNCTION: Natural electron acceptor for a formate dehydrogenase.
CC   -!- SUBCELLULAR LOCATION: Periplasm.
CC   -!- PTM: Binds 1 heme c group covalently per subunit.
CC   -!- SIMILARITY: Belongs to the cytochrome c family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE000511; AAD08272.1; -; Genomic_DNA.
DR   PIR; C64673; C64673.
DR   RefSeq; NP_208019.1; NC_000915.1.
DR   RefSeq; WP_000755879.1; NC_018939.1.
DR   AlphaFoldDB; O25825; -.
DR   SMR; O25825; -.
DR   STRING; 85962.C694_06335; -.
DR   PaxDb; O25825; -.
DR   EnsemblBacteria; AAD08272; AAD08272; HP_1227.
DR   KEGG; hpy:HP_1227; -.
DR   PATRIC; fig|85962.47.peg.1315; -.
DR   eggNOG; COG2863; Bacteria.
DR   OMA; MSMAMKA; -.
DR   PhylomeDB; O25825; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   Gene3D; 1.10.760.10; -; 1.
DR   InterPro; IPR009056; Cyt_c-like_dom.
DR   InterPro; IPR036909; Cyt_c-like_dom_sf.
DR   InterPro; IPR008168; Cyt_C_IC.
DR   Pfam; PF13442; Cytochrome_CBB3; 1.
DR   PRINTS; PR00605; CYTCHROMECIC.
DR   SUPFAM; SSF46626; SSF46626; 1.
DR   PROSITE; PS51007; CYTC; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Electron transport; Heme; Iron; Metal-binding;
KW   Periplasm; Reference proteome; Signal; Transport.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000269|PubMed:10965034"
FT   CHAIN           20..96
FT                   /note="Cytochrome c-553"
FT                   /id="PRO_0000006537"
FT   BINDING         29
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /note="covalent"
FT   BINDING         32
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /note="covalent"
FT   BINDING         33
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00433"
FT   BINDING         73
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00433"
SQ   SEQUENCE   96 AA;  10346 MW;  C6EEFEA2AE5B8428 CRC64;
     MKKVIMALGV LAFANALMAT DVKALAKSCA ACHGVKFEKK ALGKSKIVNM MSEAEIEKDL
     MDFKSGANKN PIMSAQAKKL SDEDIKALAK YIPTLK