CYA3_RHIME
ID CYA3_RHIME Reviewed; 587 AA.
AC Q9Z3Q0;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2001, sequence version 2.
DT 25-MAY-2022, entry version 133.
DE RecName: Full=Putative adenylate cyclase 3;
DE EC=4.6.1.1;
DE AltName: Full=ATP pyrophosphate-lyase 3;
DE AltName: Full=Adenylyl cyclase 3;
GN Name=cya3; Synonyms=cyaF5; OrderedLocusNames=RA0861; ORFNames=SMa1583;
OS Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS meliloti).
OG Plasmid pSymA (megaplasmid 1).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX NCBI_TaxID=266834;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=CXM1-105;
RX PubMed=10485295; DOI=10.1007/s004380051052;
RA Sharypova L.A., Yurgel S.N., Keller M., Simarov B.V., Puehler A.,
RA Becker A.;
RT "The eff-482 locus of Sinorhizobium meliloti CXM1-105 that influences
RT symbiotic effectiveness consists of three genes encoding an endoglycanase,
RT a transcriptional regulator and an adenylate cyclase.";
RL Mol. Gen. Genet. 261:1032-1044(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX PubMed=11481432; DOI=10.1073/pnas.161294798;
RA Barnett M.J., Fisher R.F., Jones T., Komp C., Abola A.P., Barloy-Hubler F.,
RA Bowser L., Capela D., Galibert F., Gouzy J., Gurjal M., Hong A., Huizar L.,
RA Hyman R.W., Kahn D., Kahn M.L., Kalman S., Keating D.H., Palm C.,
RA Peck M.C., Surzycki R., Wells D.H., Yeh K.-C., Davis R.W., Federspiel N.A.,
RA Long S.R.;
RT "Nucleotide sequence and predicted functions of the entire Sinorhizobium
RT meliloti pSymA megaplasmid.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:9883-9888(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX PubMed=11474104; DOI=10.1126/science.1060966;
RA Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA Wong K., Yeh K.-C., Batut J.;
RT "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL Science 293:668-672(2001).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK65519.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AJ225896; CAB38103.1; -; Genomic_DNA.
DR EMBL; AE006469; AAK65519.2; ALT_INIT; Genomic_DNA.
DR PIR; E95369; E95369.
DR RefSeq; NP_436107.2; NC_003037.1.
DR RefSeq; WP_015242161.1; NC_003037.1.
DR AlphaFoldDB; Q9Z3Q0; -.
DR SMR; Q9Z3Q0; -.
DR EnsemblBacteria; AAK65519; AAK65519; SMa1583.
DR GeneID; 25011728; -.
DR GeneID; 61599632; -.
DR KEGG; sme:SMa1583; -.
DR PATRIC; fig|266834.11.peg.895; -.
DR HOGENOM; CLU_019981_0_0_5; -.
DR Proteomes; UP000001976; Plasmid pSymA.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 1.25.40.10; -; 1.
DR Gene3D; 3.30.70.1230; -; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; SSF48452; 1.
DR SUPFAM; SSF55073; SSF55073; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50005; TPR; 4.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW ATP-binding; cAMP biosynthesis; Lyase; Nucleotide-binding; Plasmid;
KW Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..587
FT /note="Putative adenylate cyclase 3"
FT /id="PRO_0000195746"
FT DOMAIN 12..127
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00099"
FT REPEAT 343..376
FT /note="TPR 1"
FT REPEAT 421..454
FT /note="TPR 2"
FT REPEAT 455..488
FT /note="TPR 3"
FT REPEAT 490..522
FT /note="TPR 4"
FT REPEAT 524..556
FT /note="TPR 5"
FT CONFLICT 18
FT /note="A -> T (in Ref. 1; CAB38103)"
FT /evidence="ECO:0000305"
FT CONFLICT 178
FT /note="R -> H (in Ref. 1; CAB38103)"
FT /evidence="ECO:0000305"
FT CONFLICT 183
FT /note="P -> L (in Ref. 1; CAB38103)"
FT /evidence="ECO:0000305"
FT CONFLICT 196..197
FT /note="KP -> S (in Ref. 1; CAB38103)"
FT /evidence="ECO:0000305"
FT CONFLICT 251
FT /note="D -> N (in Ref. 1; CAB38103)"
FT /evidence="ECO:0000305"
FT CONFLICT 553
FT /note="N -> D (in Ref. 1; CAB38103)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 587 AA; 65307 MW; 4630AC9816FB615D CRC64;
MAKESIRRRL AAILAADAVG YSRLMERDEK STHTLLMARW KEVLEPLVGI HQGRVFKRTG
DGVLVEFGSA VNAVECAAAL QQAMAAANRD LPEDRAIVLR VGVNLGDIMV EDSDLFGDGV
NVAARIEALA DPGGVAISDG IHEYVHGRTD IDFVDSGYHE VKNIERPVHI WTWSPKDRAR
EPPNIAAEPP PQLPAKPSIA VLPFDNMSGD PEQGYFADGI TEDIITDLSK VSGLFVIARN
SSFAYKGKTP DIRKVSRELG VRYVLEGSVR RAANRIRINA QMIDGTTGGH LWAERYDRGL
EDIFAVQDEV TRTIVNALRV KLTAGEEERR ESRGKVDPEA YDLLVRSRQA ILQFNALSSM
EARRMLHRVL EIDPGMAAAH ASLSIIALTD FINQWNGATP DNLTQALGLA QEAIDTDGSE
PQGHYTLALA LSWMRRLDEA EHAAERAIEL DPNSANAYTA LGTIRDFQGR HEEALALYTR
AHRLDPQFDL SLHFQGRALL NLGRFDEAEV AFKRRLLLAP RSDMTRFYLA CLYGRTGRHE
EARGYWREVL GVNPSFSVDH LRRSLPYQDP HLMDRLVEGL REAGVSI
