ID   CYAA_TRYEQ              Reviewed;         469 AA.
AC   P26338;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Receptor-type adenylate cyclase;
DE            EC=4.6.1.1;
DE   AltName: Full=ATP pyrophosphate-lyase;
DE   AltName: Full=Adenylyl cyclase;
DE   Flags: Fragment;
GN   Name=ESAG4C;
OS   Trypanosoma equiperdum.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=5694;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CL;
RX   PubMed=2065652; DOI=10.1002/j.1460-2075.1991.tb07735.x;
RA   Ross D.T., Raibaud A., Florent I.C., Sather S., Gross M.K., Storm D.R.,
RA   Eisen H.;
RT   "The trypanosome VSG expression site encodes adenylate cyclase and a
RT   leucine-rich putative regulatory gene.";
RL   EMBO J. 10:2047-2053(1991).
CC   -!- FUNCTION: Could act as a receptor for an unknown ligand.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC       Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC       {ECO:0000305}.
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DR   EMBL; X59386; CAA42029.1; -; Genomic_DNA.
DR   PIR; S16359; S16359.
DR   AlphaFoldDB; P26338; -.
DR   SMR; P26338; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   Gene3D; 3.30.70.1230; -; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; SSF55073; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; cAMP biosynthesis; Cell membrane; Glycoprotein; Lyase;
KW   Magnesium; Membrane; Metal-binding; Nucleotide-binding; Receptor;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           <1..469
FT                   /note="Receptor-type adenylate cyclase"
FT                   /id="PRO_0000195741"
FT   TOPO_DOM        <1..59
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        81..469
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          103..257
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00099"
FT   BINDING         108
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         151
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        31
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
SQ   SEQUENCE   469 AA;  50819 MW;  F87638C3152DEA3A CRC64;
     VDTAEKLSKN GCASNYGATQ ISVWSMARAL NASIPPLTNP MTPSMTFRNS NAGRISGVAL
     VGVIIGGALA LFLVVALGVV PYFFLHNTRD NNLAPKELTD PVTLIFTDIE SSTALWAAHP
     ELMPDAVATH HRLIRSLIGR YGCYEVKTVG DSFMIASKSP FAAVQLAQEL QLCFLHHDWG
     TNAIDESYQQ LEQQRAEEDA KYTPPTARLD LKVYSRLWNG LRVRVGIHTG LCDIRRDEVT
     KGYDYYGRTS NMAARTESVG NGGQVLMTTA AYMSLSAEER EQIDVTALGD VPLRGVAKPV
     EMYQLNAVPG RTFAGLRLEH ELLNDDEDQT TTSCSDHSSS RTDLSVAAQT IAASLQSLLG
     TFTPAQRQKA LIPFCERWRV PLPQKVGNVW DNDGCQEAIR RVAAKVGRVM DFGTRKASSS
     VTSLERGGSL FSAGGATVAT VASSSNFSCV DGRCGTVQLI DLENDSTTS