CYAA_YERPE
ID CYAA_YERPE Reviewed; 850 AA.
AC P40127; Q0WAG2;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2001, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Adenylate cyclase;
DE EC=4.6.1.1;
DE AltName: Full=ATP pyrophosphate-lyase;
DE AltName: Full=Adenylyl cyclase;
GN Name=cya; Synonyms=cyaA; OrderedLocusNames=YPO3848, y0382, YP_3199;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=EV 40;
RX PubMed=8874804; DOI=10.1016/0300-9084(96)82192-4;
RA Trotot P., Sismeiro O., Vivares C., Glaser P., Bresson-Roy A., Danchin A.;
RT "Comparative analysis of the cya locus in enterobacteria and related Gram-
RT negative facultative anaerobes.";
RL Biochimie 78:277-287(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
RN [5]
RP REVIEW.
RX PubMed=8418825;
RA Danchin A.;
RT "Phylogeny of adenylyl cyclases.";
RL Adv. Second Messenger Phosphoprotein Res. 27:109-162(1993).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC -!- ACTIVITY REGULATION: The regulatory domain is involved in the
CC regulation of cyclase activity by the carbon source.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-1 family.
CC {ECO:0000305}.
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DR EMBL; U22968; AAC44324.1; -; Genomic_DNA.
DR EMBL; AL590842; CAL22435.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM83971.1; -; Genomic_DNA.
DR EMBL; AE017042; AAS63367.1; -; Genomic_DNA.
DR PIR; AH0468; AH0468.
DR RefSeq; WP_002211468.1; NZ_WUCM01000033.1.
DR RefSeq; YP_002348726.1; NC_003143.1.
DR AlphaFoldDB; P40127; -.
DR IntAct; P40127; 9.
DR STRING; 214092.YPO3848; -.
DR PaxDb; P40127; -.
DR EnsemblBacteria; AAM83971; AAM83971; y0382.
DR EnsemblBacteria; AAS63367; AAS63367; YP_3199.
DR GeneID; 57974861; -.
DR KEGG; ype:YPO3848; -.
DR KEGG; ypk:y0382; -.
DR KEGG; ypm:YP_3199; -.
DR PATRIC; fig|214092.21.peg.4372; -.
DR eggNOG; COG3072; Bacteria.
DR HOGENOM; CLU_013280_0_0_6; -.
DR OMA; YDDYVMS; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004016; F:adenylate cyclase activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR InterPro; IPR000274; Adenylate_cyclase_1.
DR InterPro; IPR024686; Adenylate_cyclase_1_CS.
DR InterPro; IPR024685; Adenylate_cyclase_1_N.
DR PANTHER; PTHR38760; PTHR38760; 1.
DR Pfam; PF12633; Adenyl_cycl_N; 1.
DR Pfam; PF01295; Adenylate_cycl; 1.
DR PIRSF; PIRSF001444; Adenylate_cycl; 1.
DR PROSITE; PS01092; ADENYLATE_CYCLASE_1_1; 1.
DR PROSITE; PS01093; ADENYLATE_CYCLASE_1_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; cAMP biosynthesis; Cytoplasm; Lyase; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..850
FT /note="Adenylate cyclase"
FT /id="PRO_0000195680"
FT REGION 1..535
FT /note="Catalytic"
FT /evidence="ECO:0000255"
FT REGION 541..850
FT /note="Regulatory"
FT /evidence="ECO:0000255"
FT CONFLICT 220..221
FT /note="AQ -> RE (in Ref. 1; AAC44324)"
FT /evidence="ECO:0000305"
FT CONFLICT 277
FT /note="N -> K (in Ref. 1; AAC44324)"
FT /evidence="ECO:0000305"
FT CONFLICT 334
FT /note="C -> R (in Ref. 4; AAS63367)"
FT /evidence="ECO:0000305"
FT CONFLICT 550
FT /note="R -> C (in Ref. 1; AAC44324)"
FT /evidence="ECO:0000305"
FT CONFLICT 572
FT /note="H -> D (in Ref. 1; AAC44324)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 850 AA; 96907 MW; 7B228C81D690B11F CRC64;
MYLYIETLKQ RLDAINQLRV DRALAAMGPA FQKVYSLLPI LLHCHHPQMP GYLDGNVPHG
VCLFTPNEIQ QDYLADVEAR WGEPLAPSAG GELPITGVYS MGSTSSIGQC HTSDLDIWVC
HQAWLDTEER NQLQQKCSLL EKWAASMGVE VSFFLVDENR FRHNASGSLG GEDCGSTQHI
LLLDEFYRSA VRLAGKRILW NMVPVKEEEH YDDYVLSLYA QGVLTPNEWL DLGGLSTLSA
EEYFGASLWQ LYKSIDSPYK AVLKTLLLEA YSWEYPNSQL LAMEIKQHLH AGEIVSFGLD
AYCMMLDRVT RYLIQINDTT RLNLVRRCFY LKVCEKLSRT PASTGWRREV LSQLVSEWGW
SNEKLAVLDN RANWKIERVR EAHNELLDAM MQSYRNLIRF ARRNNLSVSA SPQDIGVLTR
KLYAAFEALP GKVTLVNPQI SPDLSEEHLT FIHVPAGRAN RPGWYLYNQA PSMDAIVSHQ
PLEYNRYLNK LVSWAYFNGL LTSKTHLHIK SANLCDTVKL QELVTDISHH FPLRLAAPTP
KALYSPCEIR HLAIIVNLEH DPTTTFRNQV VHFDFRKLDV FSFGEQQQCL VGSIDLLYRN
SWNEVRTLHF SGEQAVLEAL KTILGKMHQD AAPPESVDVF CYSQHLRGLI RTRIQQLVSE
CIDLRLSSTR QEPGRFKAVR VSGQTWGLFF ERLSVSVQKL ENAVEFYGAI SNNKLHGLSV
QVETNQIHLP PVVDGFASEG IIQFFFEGTA DEKGFNIYIL DEANRVEVYH HCEGSKEELV
RDVSRFYSSS HDRFTYGSSF INFNLPQFYQ IVQLDGRTQV IPFRSNTLSQ LCANIAEKEA
SLPTKQCQLH
