ID   CYAD_AMAPH              Reviewed;           8 AA.
AC   P0CU60;
DT   28-MAR-2018, integrated into UniProtKB/Swiss-Prot.
DT   28-MAR-2018, sequence version 1.
DT   26-FEB-2020, entry version 5.
DE   RecName: Full=Cycloamanide D {ECO:0000303|PubMed:8441706};
DE            Short=CyA D {ECO:0000303|PubMed:8441706};
DE            Short=Cyl D {ECO:0000303|PubMed:28866879};
OS   Amanita phalloides (Death cap).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Amanitaceae; Amanita.
OX   NCBI_TaxID=67723;
RN   [1]
RP   FUNCTION.
RX   PubMed=8441706; DOI=10.1016/0196-9781(93)90003-y;
RA   Wieczorek Z., Siemion I.Z., Zimecki M., Bolewska-Pedyczak E., Wieland T.;
RT   "Immunosuppressive activity in the series of cycloamanide peptides from
RT   mushrooms.";
RL   Peptides 14:1-5(1993).
RN   [2]
RP   CYCLIZATION.
RX   PubMed=28866879; DOI=10.1021/acssynbio.7b00264;
RA   Sgambelluri R.M., Smith M.O., Walton J.D.;
RT   "Versatility of prolyl oligopeptidase B in peptide macrocyclization.";
RL   ACS Synth. Biol. 7:145-152(2018).
CC   -!- FUNCTION: Cyclic octapeptide that belongs to the MSDIN-like toxin
CC       family responsible for a large number of food poisoning cases and
CC       deaths (PubMed:8441706, PubMed:28866879). Cycloaminide B is non-toxic
CC       to mammals but shows immunosuppressive activity, probably through the
CC       inhibition of the action of interleukin-1 and interleukin-2
CC       (PubMed:8441706). {ECO:0000269|PubMed:28866879,
CC       ECO:0000269|PubMed:8441706}.
CC   -!- PTM: Processed by the macrocyclase-peptidase enzyme POPB to yield a
CC       cyclic octapeptide (PubMed:28866879). POPB first removes 10 residues
CC       from the N-terminus (By similarity). Conformational trapping of the
CC       remaining peptide forces the enzyme to release this intermediate rather
CC       than proceed to macrocyclization (By similarity). The enzyme rebinds
CC       the remaining peptide in a different conformation and catalyzes
CC       macrocyclization of the N-terminal 8 residues (PubMed:28866879).
CC       {ECO:0000250|UniProtKB:A0A067SLB9, ECO:0000269|PubMed:28866879}.
CC   -!- SIMILARITY: Belongs to the MSDIN fungal toxin family. {ECO:0000305}.
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DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Toxin.
FT   PEPTIDE         1..8
FT                   /note="Cycloamanide D"
FT                   /evidence="ECO:0000305|PubMed:8441706"
FT                   /id="PRO_0000443782"
FT   CROSSLNK        1..8
FT                   /note="Cyclopeptide (Met-Pro)"
FT                   /evidence="ECO:0000269|PubMed:28866879"
SQ   SEQUENCE   8 AA;  887 MW;  EE67376729C87726 CRC64;
     MLGFLPLP