ID   CYAD_BORPE              Reviewed;         440 AA.
AC   P0DKX9; P11091;
DT   06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2013, sequence version 1.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=Protein CyaD;
GN   Name=cyaD; OrderedLocusNames=BP0762;
OS   Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=257313;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tohama I / ATCC BAA-589 / NCTC 13251;
RX   PubMed=12910271; DOI=10.1038/ng1227;
RA   Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA   Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA   Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA   Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA   Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T.,
RA   Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S.,
RA   Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E.,
RA   Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M.,
RA   Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S.,
RA   Barrell B.G., Maskell D.J.;
RT   "Comparative analysis of the genome sequences of Bordetella pertussis,
RT   Bordetella parapertussis and Bordetella bronchiseptica.";
RL   Nat. Genet. 35:32-40(2003).
CC   -!- FUNCTION: CyaD is necessary for transport of calmodulin-sensitive
CC       adenylate cyclase-hemolysin (cyclolysin). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000305}.
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DR   EMBL; BX640413; CAE41068.1; -; Genomic_DNA.
DR   RefSeq; NP_879580.1; NC_002929.2.
DR   RefSeq; WP_010929997.1; NZ_CP039022.1.
DR   AlphaFoldDB; P0DKX9; -.
DR   SMR; P0DKX9; -.
DR   STRING; 257313.BP0762; -.
DR   GeneID; 45387799; -.
DR   KEGG; bpe:BP0762; -.
DR   PATRIC; fig|257313.5.peg.815; -.
DR   eggNOG; COG0845; Bacteria.
DR   HOGENOM; CLU_023976_0_1_4; -.
DR   OMA; EIKPGMP; -.
DR   Proteomes; UP000002676; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR   InterPro; IPR006144; Secretion_HlyD_CS.
DR   InterPro; IPR010129; T1SS_HlyD.
DR   Pfam; PF13533; Biotin_lipoyl_2; 1.
DR   TIGRFAMs; TIGR01843; type_I_hlyD; 1.
DR   PROSITE; PS00543; HLYD_FAMILY; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Cytolysis; Hemolysis; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..440
FT                   /note="Protein CyaD"
FT                   /id="PRO_0000201866"
FT   TOPO_DOM        1..55
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        76..440
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   440 AA;  48054 MW;  27B773B66BD00FF3 CRC64;
     MRRALRELAA RHGRVLAASW RQRHRRPAGW FDPVETEFLP SALSLQERPI SPTARWLARI
     LMALAAGALV WSVVGKTEIV VHAAGKVVPV GQSKIIAASE TGRVARVLVA DNSRVAAGDV
     LLRLDAGVTE AEERKWRVQA AQARQDEARS RAMIRALDTG RAPVLAELPA DPGMMAAQSY
     LDSQYADYQA QLRSIEAAIA TYRRELGLVT QIAHAHRGLR RDGDVSQQAY LEKEQARMTL
     EGRLRQSEAQ RAALQTQTRR QAFETLVLAR KLAAQAEQEI ARTSAQRSRL VLTAPVDGVV
     QQLVALTEGT AVAATQPLMM VVPSGAGIQV QAQLDSKDIG FVRAGAPATV KVGAYDYTKY
     GTLEGKVLYV SPDTVVDDRQ QHSYRVTIAL AHPALEVDGK PRLLKEGMAV QADIRTGSRR
     LIEYLLSPVA RHAGESLGER