ID   CYAE_BORPE              Reviewed;         474 AA.
AC   P0DKY0; P11092;
DT   06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2013, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Protein CyaE;
DE   Flags: Precursor;
GN   Name=cyaE; OrderedLocusNames=BP0763;
OS   Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=257313;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tohama I / ATCC BAA-589 / NCTC 13251;
RX   PubMed=12910271; DOI=10.1038/ng1227;
RA   Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA   Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA   Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA   Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA   Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T.,
RA   Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S.,
RA   Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E.,
RA   Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M.,
RA   Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S.,
RA   Barrell B.G., Maskell D.J.;
RT   "Comparative analysis of the genome sequences of Bordetella pertussis,
RT   Bordetella parapertussis and Bordetella bronchiseptica.";
RL   Nat. Genet. 35:32-40(2003).
CC   -!- FUNCTION: CyaE is necessary for transport of calmodulin-sensitive
CC       adenylate cyclase-hemolysin (cyclolysin). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the outer membrane factor (OMF) (TC 1.B.17)
CC       family. {ECO:0000305}.
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DR   EMBL; BX640413; CAE41069.1; -; Genomic_DNA.
DR   RefSeq; NP_879581.1; NC_002929.2.
DR   RefSeq; WP_010929998.1; NZ_CP039022.1.
DR   AlphaFoldDB; P0DKY0; -.
DR   SMR; P0DKY0; -.
DR   STRING; 257313.BP0763; -.
DR   GeneID; 45387800; -.
DR   KEGG; bpe:BP0763; -.
DR   PATRIC; fig|257313.5.peg.816; -.
DR   eggNOG; COG1538; Bacteria.
DR   HOGENOM; CLU_012817_10_2_4; -.
DR   OMA; SQTIWDS; -.
DR   Proteomes; UP000002676; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR028351; CyaE.
DR   InterPro; IPR003423; OMP_efflux.
DR   Pfam; PF02321; OEP; 2.
DR   PIRSF; PIRSF001892; CyaE; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Cytolysis; Hemolysis; Membrane; Reference proteome;
KW   Signal; Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000255"
FT   CHAIN           32..474
FT                   /note="Protein CyaE"
FT                   /id="PRO_0000013350"
SQ   SEQUENCE   474 AA;  50205 MW;  29A4F21D377FC957 CRC64;
     MAAVQVRRRG RALALALWAG FALSVGGGVR ARDGLATPPA FEGQAAPAVS WPCPPPADRL
     DDLALLEAID LALCHSPALR QGWARIKARS AEVGLARAPY YPSVALSAGR SAQRRSTGLG
     EDGVRNNVMA VTLAWRLFDS GARSAALRAA QAQLDEAAQA YGAVLQDKLA EVVGAYYEAA
     TARQALHTAV EDTEIARRSA SIAARRARAG LDSHGDVLHA QAALERARLA QAQAEGAQAR
     ALAGLAQVLG VDPATPIVLA PGPLAPQRIE DRELAQWLRD ARQRHPAIKA AQAGLAAATA
     QVDVARATDM PTVDLSLGHY RNSSENVSVF AGSSRSVSAS LNLRIPLFDG FARRHRIQGA
     RAEVQRQEAL LDQARLATGA AVARAYADLR AARASHEASL RWLKAARAAY ESDLRRYEAG
     VGGVAELLRA QSDWLSARQR HVLYAAQLRT RALALLAAAG ELGRSTIDGD PPKE