CYAF_AMAPH
ID CYAF_AMAPH Reviewed; 35 AA.
AC P0CU62;
DT 28-MAR-2018, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 1.
DT 25-MAY-2022, entry version 6.
DE RecName: Full=Cycloamanide F proprotein {ECO:0000303|PubMed:27978833};
DE Contains:
DE RecName: Full=Cycloamanide F {ECO:0000303|PubMed:27978833};
DE Flags: Precursor;
OS Amanita phalloides (Death cap).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Amanitaceae; Amanita.
OX NCBI_TaxID=67723;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND FUNCTION.
RX PubMed=27978833; DOI=10.1186/s12864-016-3378-7;
RA Pulman J.A., Childs K.L., Sgambelluri R.M., Walton J.D.;
RT "Expansion and diversification of the MSDIN family of cyclic peptide genes
RT in the poisonous agarics Amanita phalloides and A. bisporigera.";
RL BMC Genomics 17:1038-1038(2016).
CC -!- FUNCTION: Cyclic octapeptide that belongs to the MSDIN-like toxin
CC family responsible for a large number of food poisoning cases and
CC deaths (PubMed:27978833). Cycloaminide E is structurally related to
CC other cycloamanides that are non-toxic to mammals but show
CC immunosuppressive activity (PubMed:27978833).
CC {ECO:0000305|PubMed:27978833}.
CC -!- PTM: Processed by the macrocyclase-peptidase enzyme POPB to yield a
CC cyclic decapeptide (By similarity). POPB first removes 10 residues from
CC the N-terminus (By similarity). Conformational trapping of the
CC remaining peptide forces the enzyme to release this intermediate rather
CC than proceed to macrocyclization (By similarity). The enzyme rebinds
CC the remaining peptide in a different conformation and catalyzes
CC macrocyclization of the N-terminal 8 residues (By similarity).
CC {ECO:0000250|UniProtKB:A0A067SLB9}.
CC -!- SIMILARITY: Belongs to the MSDIN fungal toxin family. {ECO:0000305}.
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DR AlphaFoldDB; P0CU62; -.
DR SMR; P0CU62; -.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR027582; Amanitin/phalloidin.
DR TIGRFAMs; TIGR04309; amanitin; 1.
PE 3: Inferred from homology;
KW Toxin.
FT PROPEP 1..10
FT /evidence="ECO:0000305|PubMed:27978833"
FT /id="PRO_0000443786"
FT PEPTIDE 11..18
FT /note="Cycloamanide F"
FT /evidence="ECO:0000305|PubMed:27978833"
FT /id="PRO_0000443787"
FT PROPEP 19..35
FT /evidence="ECO:0000305|PubMed:27978833"
FT /id="PRO_0000443788"
FT CROSSLNK 11..18
FT /note="Cyclopeptide (Ile-Pro)"
FT /evidence="ECO:0000305|PubMed:27978833"
SQ SEQUENCE 35 AA; 3654 MW; 8A73A5B400B057DD CRC64;
MSDINATRLP IVGILGLPCI GDDVNSTLTH GEDLC