ID   36011_ASFM2             Reviewed;         353 AA.
AC   Q65123;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Protein MGF 360-11L;
GN   OrderedLocusNames=Mal-030; ORFNames=LMW3EL;
OS   African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983) (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=10500;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=85517; Phacochoerus aethiopicus (Warthog).
OH   NCBI_TaxID=41426; Phacochoerus africanus (Warthog).
OH   NCBI_TaxID=273792; Potamochoerus larvatus (Bushpig).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8030263; DOI=10.1006/viro.1994.1426;
RA   Yozawa T., Kutish G.F., Afonso C.L., Lu Z., Rock D.L.;
RT   "Two novel multigene families, 530 and 300, in the terminal variable
RT   regions of African swine fever virus genome.";
RL   Virology 202:997-1002(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Kutish G.F., Rock D.L.;
RT   "African swine fever virus genomes.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in virus cell tropism, and may be required for
CC       efficient virus replication in macrophages. In addition, inhibits the
CC       phosphorylation of host TBK1 and IRF7 and thereby negatively regulates
CC       the host cGAS signaling pathway and antagonizes IFN-mediated antiviral
CC       activity. {ECO:0000250|UniProtKB:P0C9P6}.
CC   -!- SUBUNIT: Interacts with host TBK1 ad IRF7.
CC       {ECO:0000250|UniProtKB:P0C9P6}.
CC   -!- SIMILARITY: Belongs to the asfivirus MGF 360 family. {ECO:0000305}.
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DR   EMBL; U03762; AAA50536.1; -; Genomic_DNA.
DR   EMBL; AY261361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; Q65123; -.
DR   PRIDE; Q65123; -.
DR   Proteomes; UP000000860; Genome.
DR   GO; GO:0039722; P:suppression by virus of host toll-like receptor signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0039557; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity; IEA:UniProtKB-KW.
DR   GO; GO:0039723; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity; IEA:UniProtKB-KW.
DR   GO; GO:0042330; P:taxis; IEA:InterPro.
DR   InterPro; IPR002595; ASFV_MGF360.
DR   Pfam; PF01671; ASFV_360; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction; Inhibition of host innate immune response by virus;
KW   Inhibition of host IRF7 by virus; Inhibition of host RLR pathway by virus;
KW   Inhibition of host TBK1 by virus; Inhibition of host TLR pathway by virus;
KW   Viral immunoevasion.
FT   CHAIN           1..353
FT                   /note="Protein MGF 360-11L"
FT                   /id="PRO_0000373279"
SQ   SEQUENCE   353 AA;  41804 MW;  54AA3A62F4F738C3 CRC64;
     MLPSLQSLTK KVLAKQCVPV DQYHVLKCCG LWWYDGPITF YVYRHKMFIR STCFSEGIEL
     NTVLMKAAKE NNHDLIRLFA EWGADINYGL ICAHTEHTRN LCRELGAKDR LDRDYILKIF
     FDTTRNKTDS NIILCHEMFS NNPNLKNVDN LDLREEIMWE LRGLMEITYM LDHDNSFSNM
     LTKYWYAIAV DYGLKKAIHY FYQRYTHLHH WRLMCALFYN NVFDLHELYV IERVRMDIDE
     MMHIACVQDY SYAAIYYCFI MGANINQAML VSIQNYNLGN MFFCIDLGAN AFEEGKALAE
     QKENYLIADA LSLKHYNPVI SLLSVIMDPE KINCMLKNYH SINMRVFLDY ERR