ID   CYB5R_DROVI             Reviewed;         142 AA.
AC   P50266;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Cytochrome b5-related protein;
GN   Name=Cyt-b5-r;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7563130; DOI=10.1007/bf00160314;
RA   Kula M.E., Allay E.R., Rozek C.E.;
RT   "Evolutionary divergence of the cytochrome b5 gene of Drosophila.";
RL   J. Mol. Evol. 41:430-439(1995).
CC   -!- FUNCTION: May play a role in muscle cell metabolism. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytochrome b5 family. {ECO:0000305}.
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DR   EMBL; U12418; AAA85492.1; -; Genomic_DNA.
DR   AlphaFoldDB; P50266; -.
DR   SMR; P50266; -.
DR   STRING; 7244.FBpp0238478; -.
DR   eggNOG; KOG4232; Eukaryota.
DR   ChiTaRS; Cyt-b5-r; fly.
DR   GO; GO:0005739; C:mitochondrion; IEA:EnsemblMetazoa.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.120.10; -; 1.
DR   InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR   InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR   InterPro; IPR018506; Cyt_B5_heme-BS.
DR   Pfam; PF00173; Cyt-b5; 1.
DR   PRINTS; PR00363; CYTOCHROMEB5.
DR   SMART; SM01117; Cyt-b5; 1.
DR   SUPFAM; SSF55856; SSF55856; 1.
DR   PROSITE; PS00191; CYTOCHROME_B5_1; 1.
DR   PROSITE; PS50255; CYTOCHROME_B5_2; 1.
PE   3: Inferred from homology;
KW   Heme; Iron; Metal-binding.
FT   CHAIN           1..142
FT                   /note="Cytochrome b5-related protein"
FT                   /id="PRO_0000166019"
FT   DOMAIN          16..100
FT                   /note="Cytochrome b5 heme-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00279"
FT   BINDING         59
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00279"
FT   BINDING         82
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00279"
SQ   SEQUENCE   142 AA;  16707 MW;  287EBEA44AE7652D CRC64;
     MVIETWKKSG IATKFPTYRN SAPVTVHSWQ KGKRQDVEAE GLWRIKDGIY DFTEFIDKHP
     GGTFWIRETK GTDITEAFEA HHLTTAPEKM IAKYKVRDAY QRIYTLTLHE DGFYKTLKER
     VREKLKTIDK RPKRKSDVSD DL