ID   36011_ASFP4             Reviewed;         353 AA.
AC   P0C9P8;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 25.
DE   RecName: Full=Protein MGF 360-11L;
GN   OrderedLocusNames=Pret-033;
OS   African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996)
OS   (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=561443;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=85517; Phacochoerus aethiopicus (Warthog).
OH   NCBI_TaxID=41426; Phacochoerus africanus (Warthog).
OH   NCBI_TaxID=273792; Potamochoerus larvatus (Bushpig).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Kutish G.F., Rock D.L.;
RT   "African swine fever virus genomes.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in virus cell tropism, and may be required for
CC       efficient virus replication in macrophages. In addition, inhibits the
CC       phosphorylation of host TBK1 and IRF7 and thereby negatively regulates
CC       the host cGAS signaling pathway and antagonizes IFN-mediated antiviral
CC       activity. {ECO:0000250|UniProtKB:P0C9P6}.
CC   -!- SUBUNIT: Interacts with host TBK1 ad IRF7.
CC       {ECO:0000250|UniProtKB:P0C9P6}.
CC   -!- SIMILARITY: Belongs to the asfivirus MGF 360 family. {ECO:0000305}.
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DR   EMBL; AY261363; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; P0C9P8; -.
DR   Proteomes; UP000000859; Genome.
DR   GO; GO:0039722; P:suppression by virus of host toll-like receptor signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0039557; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity; IEA:UniProtKB-KW.
DR   GO; GO:0039723; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity; IEA:UniProtKB-KW.
DR   GO; GO:0042330; P:taxis; IEA:InterPro.
DR   InterPro; IPR002595; ASFV_MGF360.
DR   Pfam; PF01671; ASFV_360; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction; Inhibition of host innate immune response by virus;
KW   Inhibition of host IRF7 by virus; Inhibition of host RLR pathway by virus;
KW   Inhibition of host TBK1 by virus; Inhibition of host TLR pathway by virus;
KW   Viral immunoevasion.
FT   CHAIN           1..353
FT                   /note="Protein MGF 360-11L"
FT                   /id="PRO_0000373278"
SQ   SEQUENCE   353 AA;  41507 MW;  78DB8CFF6DF6EDBD CRC64;
     MLPSLQSLTK KVLAGQCVSV DHYHILKCCG LWWHNGPIML HIRRNRIFIR STCFSQGIEL
     NIGLMKAVKE NNHDLIKLFT EWGADINYGM ICALTENTRD LCKELGAKEY LEREYILKIF
     FDTTRDKTSN NIIFCHEVFS NNPNLRIIDN LDLRGEIMWE LRGLMEITFM LDHDDSFSTV
     LTKYWYAIAV DYDLKDAIRY FYQKYPRLHR WRLMCALFYN NVFDLHELYE IERVRMDIDE
     MMHIACVQDY SYSAIYYCFI MGANINQAML VSIQNYNLGN LFFCIDLGAN AFEEGKALAE
     QKGNYLIANA LSLKHYNPVI SLLSVVTDPE KINRMLKNYH SINMGIFLDY EQR