ACR12_ARATH
ID ACR12_ARATH Reviewed; 301 AA.
AC Q9LZ23; Q8LB85;
DT 07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 132.
DE RecName: Full=ACT domain-containing protein ACR12 {ECO:0000305};
DE AltName: Full=Protein ACT DOMAIN REPEATS 12 {ECO:0000303|PubMed:21861936};
DE Flags: Precursor;
GN Name=ACR12 {ECO:0000303|PubMed:21861936};
GN OrderedLocusNames=At5g04740 {ECO:0000312|Araport:AT5G04740};
GN ORFNames=MUK11.6 {ECO:0000312|EMBL:BAB08978.1},
GN T1E3.100 {ECO:0000312|EMBL:CAB86016.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=21861936; DOI=10.1186/1471-2229-11-118;
RA Sung T.Y., Chung T.Y., Hsu C.P., Hsieh M.H.;
RT "The ACR11 encodes a novel type of chloroplastic ACT domain repeat protein
RT that is coordinately expressed with GLN2 in Arabidopsis.";
RL BMC Plant Biol. 11:118-118(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9501997; DOI=10.1093/dnares/4.6.401;
RA Nakamura Y., Sato S., Kaneko T., Kotani H., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. III. Sequence
RT features of the regions of 1,191,918 bp covered by seventeen physically
RT assigned P1 clones.";
RL DNA Res. 4:401-414(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in feedback regulation of amino acid
CC metabolism. {ECO:0000303|PubMed:21861936}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast
CC {ECO:0000269|PubMed:21861936}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9LZ23-1; Sequence=Displayed;
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DR EMBL; JF797177; AEP31953.1; -; mRNA.
DR EMBL; AB008271; BAB08978.1; -; Genomic_DNA.
DR EMBL; AL162972; CAB86016.1; -; Genomic_DNA.
DR EMBL; CP002688; AED90777.1; -; Genomic_DNA.
DR EMBL; AY072401; AAL62393.1; -; mRNA.
DR EMBL; AY114702; AAM48021.1; -; mRNA.
DR EMBL; AY087362; AAM64912.1; -; mRNA.
DR PIR; T48470; T48470.
DR RefSeq; NP_196094.1; NM_120556.3. [Q9LZ23-1]
DR AlphaFoldDB; Q9LZ23; -.
DR SMR; Q9LZ23; -.
DR IntAct; Q9LZ23; 1.
DR STRING; 3702.AT5G04740.1; -.
DR iPTMnet; Q9LZ23; -.
DR SwissPalm; Q9LZ23; -.
DR PaxDb; Q9LZ23; -.
DR PRIDE; Q9LZ23; -.
DR ProteomicsDB; 244395; -. [Q9LZ23-1]
DR EnsemblPlants; AT5G04740.1; AT5G04740.1; AT5G04740. [Q9LZ23-1]
DR GeneID; 830352; -.
DR Gramene; AT5G04740.1; AT5G04740.1; AT5G04740. [Q9LZ23-1]
DR KEGG; ath:AT5G04740; -.
DR Araport; AT5G04740; -.
DR TAIR; locus:2175458; AT5G04740.
DR eggNOG; ENOG502QWKY; Eukaryota.
DR HOGENOM; CLU_066532_0_0_1; -.
DR InParanoid; Q9LZ23; -.
DR OMA; HQKMEDD; -.
DR PhylomeDB; Q9LZ23; -.
DR PRO; PR:Q9LZ23; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LZ23; baseline and differential.
DR Genevisible; Q9LZ23; AT.
DR GO; GO:0009507; C:chloroplast; IDA:TAIR.
DR GO; GO:0009570; C:chloroplast stroma; HDA:TAIR.
DR GO; GO:0009535; C:chloroplast thylakoid membrane; HDA:TAIR.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR InterPro; IPR040217; ACR1-12.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR PANTHER; PTHR31096; PTHR31096; 1.
DR SUPFAM; SSF55021; SSF55021; 1.
DR PROSITE; PS51671; ACT; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Chloroplast; Plastid; Reference proteome; Repeat;
KW Transit peptide.
FT TRANSIT 1..57
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN 58..301
FT /note="ACT domain-containing protein ACR12"
FT /evidence="ECO:0000255"
FT /id="PRO_0000431466"
FT DOMAIN 109..189
FT /note="ACT 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01007"
FT DOMAIN 224..294
FT /note="ACT 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01007"
FT CONFLICT 17..18
FT /note="LA -> IT (in Ref. 6; AAM64912)"
FT /evidence="ECO:0000305"
FT CONFLICT 36
FT /note="A -> T (in Ref. 6; AAM64912)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 301 AA; 33242 MW; B2226F11D7C7E75C CRC64;
MAFSSSIFSV TQFSSSLASR PSSAISRQTR FPAQIASPDL SPALFDDRRK FVGGVMSLLT
KSIKNRVYAS INSIDSAATP SYPKSEDDDD VVPMPMVMID QDADPEATIV QLSFGNRLGA
LIDTMRALKD LGLDVIKGTV STEGSIKQTK FSITKRDTGR KVEDPDLLEQ IRLTIINNLL
KYHPECSEQL AMGETFGIKA PEKKIDVDIA THIHVKEDGP KRSLLVIETA DRPGLVVEMI
KVMADVNIDV ESAEIDTEGL VAKDKFHVSY QGQALNRSLS QVLVNCLRYF LRRPETDIDS
Y
