ID   ACR31_BPD31             Reviewed;          52 AA.
AC   Q6TM71;
DT   13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Anti-CRISPR protein 31 {ECO:0000303|PubMed:24736222};
DE            Short=ACR3112-31;
DE   AltName: Full=Gene product 31 {ECO:0000305};
DE            Short=gp31;
GN   Name=orf31 {ECO:0000312|EMBL:AAQ94469.1};
OS   Pseudomonas phage D3112 (Bacteriophage D3112).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Siphoviridae; Casadabanvirus.
OX   NCBI_TaxID=10708;
OH   NCBI_TaxID=287; Pseudomonas aeruginosa.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=14702309; DOI=10.1128/jb.186.2.400-410.2004;
RA   Wang P.W., Chu L., Guttman D.S.;
RT   "Complete sequence and evolutionary genomic analysis of the Pseudomonas
RT   aeruginosa transposable bacteriophage D3112.";
RL   J. Bacteriol. 186:400-410(2004).
RN   [2]
RP   FUNCTION.
RX   PubMed=24736222; DOI=10.1128/mbio.00896-14;
RA   Pawluk A., Bondy-Denomy J., Cheung V.H., Maxwell K.L., Davidson A.R.;
RT   "A new group of phage anti-CRISPR genes inhibits the type I-E CRISPR-Cas
RT   system of Pseudomonas aeruginosa.";
RL   MBio 5:E00896-E00896(2014).
RN   [3]
RP   FUNCTION.
RX   PubMed=26416740; DOI=10.1038/nature15254;
RA   Bondy-Denomy J., Garcia B., Strum S., Du M., Rollins M.F.,
RA   Hidalgo-Reyes Y., Wiedenheft B., Maxwell K.L., Davidson A.R.;
RT   "Multiple mechanisms for CRISPR-Cas inhibition by anti-CRISPR proteins.";
RL   Nature 526:136-139(2015).
CC   -!- FUNCTION: Allows the phage to evade the CRISPR/Cas system type I-E
CC       (PubMed:24736222, PubMed:26416740). Prevents the DNA-binding activity
CC       of the CRISPR-Cas complex. {ECO:0000269|PubMed:24736222,
CC       ECO:0000269|PubMed:26416740}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY394005; AAQ94469.1; -; Genomic_DNA.
DR   RefSeq; NP_938238.1; NC_005178.1.
DR   SMR; Q6TM71; -.
DR   GeneID; 2648178; -.
DR   KEGG; vg:2648178; -.
DR   Proteomes; UP000000875; Genome.
DR   GO; GO:0098672; P:inhibition of host CRISPR-cas system by virus; IEA:UniProtKB-KW.
PE   4: Predicted;
KW   CRISPR-cas system evasion by virus; Host-virus interaction;
KW   Reference proteome.
FT   CHAIN           1..52
FT                   /note="Anti-CRISPR protein 31"
FT                   /id="PRO_0000436041"
SQ   SEQUENCE   52 AA;  6047 MW;  0DAEBD54F671FA84 CRC64;
     MSTQYTYEQI AEDFRLWGEY MDPNAEMTEE EFQALSTEEK VAMQVEAFGA EA