ACR3_CAEEL
ID ACR3_CAEEL Reviewed; 487 AA.
AC Q93149;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Acetylcholine receptor subunit beta-type acr-3;
DE Flags: Precursor;
GN Name=acr-3; ORFNames=K11G12.7;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INTERACTION WITH NICOTINIC
RP ACETYLCHOLINE RECEPTOR.
RC STRAIN=Bristol N2;
RX PubMed=9606719;
RA Baylis H.A., Matsuda K., Squire M.D., Fleming J.T., Harvey R.J.,
RA Darlison M.G., Barnard E.A., Sattelle D.B.;
RT "ACR-3, a Caenorhabditis elegans nicotinic acetylcholine receptor subunit.
RT Molecular cloning and functional expression.";
RL Recept. Channels 5:149-158(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP FUNCTION, AND INTERACTION WITH NICOTINIC ACETYLCHOLINE RECEPTOR.
RX PubMed=20027209; DOI=10.1371/journal.pbio.1000265;
RA Jospin M., Qi Y.B., Stawicki T.M., Boulin T., Schuske K.R., Horvitz H.R.,
RA Bessereau J.L., Jorgensen E.M., Jin Y.;
RT "A neuronal acetylcholine receptor regulates the balance of muscle
RT excitation and inhibition in Caenorhabditis elegans.";
RL PLoS Biol. 7:E1000265-E1000265(2009).
CC -!- FUNCTION: Non-alpha subunit of nicotinic acetylcholine receptor (nAChR)
CC (PubMed:9606719, PubMed:20027209). Probably acts in cholinergic
CC motoneurons to regulate presynaptic neurotransmitter release, thereby
CC ensuring normal level of excitation of cholinergic motoneurons during
CC locomotion (PubMed:20027209). {ECO:0000269|PubMed:20027209,
CC ECO:0000269|PubMed:9606719}.
CC -!- SUBUNIT: Component of nicotinic acetylcholine receptor. In cholinergic
CC motoneurons, composed of 2 non-alpha subunits acr-2 and acr-3, and 3
CC alpha subunits unc-38, unc-63 and acr-12. {ECO:0000269|PubMed:20027209,
CC ECO:0000269|PubMed:9606719}.
CC -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane
CC {ECO:0000250|UniProtKB:Q23022}; Multi-pass membrane protein
CC {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q23022}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC Acetylcholine receptor (TC 1.A.9.1) subfamily. {ECO:0000305}.
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DR EMBL; Y08637; CAA69927.1; -; mRNA.
DR EMBL; FO081325; CCD70799.1; -; Genomic_DNA.
DR RefSeq; NP_509129.1; NM_076728.3.
DR AlphaFoldDB; Q93149; -.
DR SMR; Q93149; -.
DR STRING; 6239.K11G12.7; -.
DR TCDB; 1.A.9.1.2; the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.
DR PaxDb; Q93149; -.
DR EnsemblMetazoa; K11G12.7.1; K11G12.7.1; WBGene00000043.
DR GeneID; 180937; -.
DR KEGG; cel:CELE_K11G12.7; -.
DR UCSC; K11G12.7; c. elegans.
DR CTD; 180937; -.
DR WormBase; K11G12.7; CE28345; WBGene00000043; acr-3.
DR eggNOG; KOG3645; Eukaryota.
DR GeneTree; ENSGT00940000173310; -.
DR HOGENOM; CLU_018074_1_0_1; -.
DR InParanoid; Q93149; -.
DR OMA; VEHTGDM; -.
DR OrthoDB; 381858at2759; -.
DR PhylomeDB; Q93149; -.
DR Reactome; R-CEL-629594; Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
DR Reactome; R-CEL-629597; Highly calcium permeable nicotinic acetylcholine receptors.
DR PRO; PR:Q93149; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00000043; Expressed in larva.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IDA:WormBase.
DR GO; GO:0005231; F:excitatory extracellular ligand-gated ion channel activity; IBA:GO_Central.
DR GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IDA:WormBase.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:1904315; F:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; IBA:GO_Central.
DR GO; GO:0098703; P:calcium ion import across plasma membrane; IDA:WormBase.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0098662; P:inorganic cation transmembrane transport; IDA:WormBase.
DR GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 1.20.58.390; -; 2.
DR Gene3D; 2.70.170.10; -; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR PANTHER; PTHR18945; PTHR18945; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00254; NICOTINICR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF63712; SSF63712; 1.
DR SUPFAM; SSF90112; SSF90112; 1.
DR TIGRFAMs; TIGR00860; LIC; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; Glycoprotein; Ion channel; Ion transport;
KW Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor;
KW Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..487
FT /note="Acetylcholine receptor subunit beta-type acr-3"
FT /id="PRO_0000000401"
FT TOPO_DOM 21..231
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 232..252
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..279
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 315..439
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 440..460
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 380..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 46
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 151..165
FT /evidence="ECO:0000250"
SQ SEQUENCE 487 AA; 56245 MW; 15D3E8D1DBF7E0F8 CRC64;
MQKIWLFSII TIFLITELQC YPNSAEERLL SYIFDGYNSL IRPVLNASSP PIEVFFSLAF
VLLINVDEKN QIMQTNVWPT MKWNDYQMQW DPREFDGIKT IRVPPDKVWL PDIVLFNNAD
GNYLVSFYSN VVVEHTGDML WVPPAVYKSS CLIDVEFFPF DEQVCSLTFG SWTFRKDELQ
LSYLSGKRHV ELNDYLPSGV WDLIDAPGLL IDERSKISYQ IKIRRKALFY TVILIMPTVL
MAFLSMMVFY LPAESSEKIT LAISILLALV VFLLVVSKIL PPTSSTIPLM AKYLLMTFIM
NMITIMVSVI IINVYFRGPA THIMPNWVKT VFLKFLPVLF VMRRPESTEK ELAKMKREKR
ERRSMKSALK TFFKRNDAKI SEQPKQTSRK DGSSSEEKLS SDAKKAIEAI EYITTHLTHD
NAFKRQREEW KFVSVVIDRL LLYLFFAVTT GGTVGILLSA PNVFEQVNQT SVIERLKQQA
AEEMLNS
