ID   36014_ASFM2             Reviewed;         357 AA.
AC   Q65127;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Protein MGF 360-14L;
GN   OrderedLocusNames=Mal-034;
OS   African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983) (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=10500;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=85517; Phacochoerus aethiopicus (Warthog).
OH   NCBI_TaxID=41426; Phacochoerus africanus (Warthog).
OH   NCBI_TaxID=273792; Potamochoerus larvatus (Bushpig).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8030263; DOI=10.1006/viro.1994.1426;
RA   Yozawa T., Kutish G.F., Afonso C.L., Lu Z., Rock D.L.;
RT   "Two novel multigene families, 530 and 300, in the terminal variable
RT   regions of African swine fever virus genome.";
RL   Virology 202:997-1002(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Kutish G.F., Rock D.L.;
RT   "African swine fever virus genomes.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in virus cell tropism, and may be required for
CC       efficient virus replication in macrophages. Inhibits also the host
CC       cGAS/STING-mediated type I interferon production by inducing host IRF3
CC       degradation through the proteasome pathway. {ECO:0000250,
CC       ECO:0000250|UniProtKB:P0C9Q5}.
CC   -!- SUBUNIT: Interacts with host IRF3 and TRIM21; these interactions
CC       mediates degradation of IRF3 through TRIM21 and ubiquitin-meditated
CC       proteolysis. {ECO:0000250|UniProtKB:P0C9Q5}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250|UniProtKB:P0C9Q5}.
CC   -!- SIMILARITY: Belongs to the asfivirus MGF 360 family. {ECO:0000305}.
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DR   EMBL; U03762; AAA50540.1; -; Genomic_DNA.
DR   EMBL; AY261361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Proteomes; UP000000860; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0039548; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity; IEA:UniProtKB-KW.
DR   GO; GO:0042330; P:taxis; IEA:InterPro.
DR   InterPro; IPR002595; ASFV_MGF360.
DR   Pfam; PF01671; ASFV_360; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host-virus interaction;
KW   Inhibition of host innate immune response by virus;
KW   Inhibition of host IRF3 by virus; Inhibition of host RLR pathway by virus;
KW   Viral immunoevasion.
FT   CHAIN           1..357
FT                   /note="Protein MGF 360-14L"
FT                   /id="PRO_0000373291"
SQ   SEQUENCE   357 AA;  41386 MW;  C57EB07183FD8181 CRC64;
     MLSLQTLAKK VVACNYLSSD YDYTLQRFGL WWDLGPIHLC NTCKQIFSYK HLQCFSEDDL
     CLEAALVKAV KSDNLELIRL FVDWGANPEY GLIRVPAVHL KRLCMELGGL TPVSESRLLE
     ILKEVADLKS CAGVLLGYDM FCHNPLLETV TRTTLDTVMY TRSKIPLTGD TAHLLLSKFW
     FALALRHNFT KAIHYFYEKH KNQLYWRLTC SLYFNNIFDL HELCCKKEIC ISPNLMMKFA
     CLREENYAAI YYCHMLGASL DYGMNLSIYN NNTLNLFFCI DLGATNFDRA RLIARRVYMY
     NLSNLFLVKQ LFSRDVSLIL DLTEPQAIYD MLNTYTSKNL KQAEEYFTAH PEIVVID