ACR4_ARATH
ID ACR4_ARATH Reviewed; 451 AA.
AC Q8LJW3; Q8GWT8; Q9LQB5;
DT 07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=ACT domain-containing protein ACR4 {ECO:0000305};
DE AltName: Full=Protein ACT DOMAIN REPEATS 4 {ECO:0000303|PubMed:12481063};
GN Name=ACR4 {ECO:0000303|PubMed:12481063};
GN OrderedLocusNames=At1g69040 {ECO:0000312|Araport:AT1G69040};
GN ORFNames=F4N2.2 {ECO:0000312|EMBL:AAF27052.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=12481063; DOI=10.1104/pp.007484;
RA Hsieh M.-H., Goodman H.M.;
RT "Molecular characterization of a novel gene family encoding ACT domain
RT repeat proteins in Arabidopsis.";
RL Plant Physiol. 130:1797-1806(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Bautista V.R., Kim C.J., Chen H., Quinitio C., Ecker J.R.;
RT "Arabidopsis ORF Clone.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 22-451.
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
CC -!- FUNCTION: May bind amino acids. {ECO:0000303|PubMed:12481063}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q8LJW3-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Highly expressed in flowers and at lower levels in
CC leaves and siliques. {ECO:0000269|PubMed:12481063}.
CC -!- INDUCTION: By the cytokinin benzyladenine (BA) and cold stress.
CC {ECO:0000269|PubMed:12481063}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF27052.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF528060; AAM93429.1; -; mRNA.
DR EMBL; AC008262; AAF27052.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002684; AEE34878.1; -; Genomic_DNA.
DR EMBL; BT029177; ABJ17112.1; -; mRNA.
DR EMBL; AK118644; BAC43240.1; -; mRNA.
DR PIR; H96714; H96714.
DR RefSeq; NP_177067.1; NM_105575.3. [Q8LJW3-1]
DR AlphaFoldDB; Q8LJW3; -.
DR STRING; 3702.AT1G69040.2; -.
DR iPTMnet; Q8LJW3; -.
DR PaxDb; Q8LJW3; -.
DR PRIDE; Q8LJW3; -.
DR ProteomicsDB; 244396; -. [Q8LJW3-1]
DR EnsemblPlants; AT1G69040.1; AT1G69040.1; AT1G69040. [Q8LJW3-1]
DR GeneID; 843236; -.
DR Gramene; AT1G69040.1; AT1G69040.1; AT1G69040. [Q8LJW3-1]
DR KEGG; ath:AT1G69040; -.
DR Araport; AT1G69040; -.
DR eggNOG; ENOG502QT1H; Eukaryota.
DR HOGENOM; CLU_031332_3_0_1; -.
DR OMA; GPESCFA; -.
DR PhylomeDB; Q8LJW3; -.
DR PRO; PR:Q8LJW3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8LJW3; baseline and differential.
DR Genevisible; Q8LJW3; AT.
DR GO; GO:0009506; C:plasmodesma; IDA:CACAO.
DR InterPro; IPR040217; ACR1-12.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR PANTHER; PTHR31096; PTHR31096; 1.
DR Pfam; PF01842; ACT; 1.
DR SUPFAM; SSF55021; SSF55021; 3.
DR PROSITE; PS51671; ACT; 4.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Repeat.
FT CHAIN 1..451
FT /note="ACT domain-containing protein ACR4"
FT /id="PRO_0000431458"
FT DOMAIN 35..118
FT /note="ACT 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01007"
FT DOMAIN 123..200
FT /note="ACT 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01007"
FT DOMAIN 259..335
FT /note="ACT 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01007"
FT DOMAIN 337..416
FT /note="ACT 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01007"
FT REGION 409..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 451 AA; 50820 MW; C71E7D1E30262324 CRC64;
MSFSQDMDNE YEKLIRRMNP PRVVIDNDSC KKATVIRVDS ANEYGILLEV VQILTDLNLT
ITKAYISSDG GWFMDVFNVT DQDGNKVTDE VVLDYIQKSL GPEACFSTSM RSVGVIPSTD
STVIELTGCD RPGLLSELSA VLTHLKCSVL NAEIWTHNTR AAAVMQVTDD LTGCGISDPE
RLSRIKNLLR NVLKGSNTPR EAKTVVSHGE VHTDRRLHQM MFEDRDYEHR LVDDDSSIQD
ERQRPDVCVD NWLDKDYSVV TVRCKDRPKL LFDTVCTLTD MQYVVFHGSV DTEGTEAFQE
YYVRHIDGSP VKSEAEKQRV IQCLEAAIKR RVSEGLKLEL CTTDRVGLLS NVTRIFRENS
LTVTRAEVKT KGGKALNTFY VSDASGYSID AKTIDSIRQT IGQTILKVKN NPQEQQQRQK
SPSHESPTRF LFGGLFKSKS FVNFGLVRSY S
