ACR5_CAEEL
ID ACR5_CAEEL Reviewed; 598 AA.
AC P54246; Q3Y417;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 02-DEC-2020, sequence version 5.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Acetylcholine receptor subunit alpha-type acr-5;
DE Flags: Precursor;
GN Name=acr-5 {ECO:0000312|WormBase:K03F8.2};
GN ORFNames=K03F8.2 {ECO:0000312|WormBase:K03F8.2};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION.
RX PubMed=23351035; DOI=10.1111/ejn.12099;
RA Sellings L., Pereira S., Qian C., Dixon-McDougall T., Nowak C., Zhao B.,
RA Tyndale R.F., van der Kooy D.;
RT "Nicotine-motivated behavior in Caenorhabditis elegans requires the
RT nicotinic acetylcholine receptor subunits acr-5 and acr-15.";
RL Eur. J. Neurosci. 37:743-756(2013).
CC -!- FUNCTION: Subunit of nicotinic acetylcholine receptor (nAChR)
CC (PubMed:23351035). Involved in nAChR sensitivity to nicotine
CC (PubMed:23351035). Modulates locomotion towards the drug nicotine
CC (PubMed:23351035). {ECO:0000269|PubMed:23351035}.
CC -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC Acetylcholine receptor (TC 1.A.9.1) subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX284603; CCD63926.1; -; Genomic_DNA.
DR PIR; T16546; T16546.
DR RefSeq; NP_498437.2; NM_066036.2.
DR AlphaFoldDB; P54246; -.
DR SMR; P54246; -.
DR STRING; 6239.K03F8.2; -.
DR TCDB; 1.A.9.1.5; the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.
DR PaxDb; P54246; -.
DR PRIDE; P54246; -.
DR EnsemblMetazoa; K03F8.2.1; K03F8.2.1; WBGene00000044.
DR UCSC; K03F8.2; c. elegans.
DR WormBase; K03F8.2; CE54125; WBGene00000044; acr-5.
DR eggNOG; KOG3645; Eukaryota.
DR HOGENOM; CLU_018074_0_2_1; -.
DR InParanoid; P54246; -.
DR OrthoDB; 406640at2759; -.
DR PhylomeDB; P54246; -.
DR Reactome; R-CEL-629594; Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
DR Reactome; R-CEL-629597; Highly calcium permeable nicotinic acetylcholine receptors.
DR PRO; PR:P54246; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00000044; Expressed in larva and 2 other tissues.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0005231; F:excitatory extracellular ligand-gated ion channel activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:1904315; F:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; IBA:GO_Central.
DR GO; GO:0071316; P:cellular response to nicotine; IMP:UniProtKB.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 1.20.58.390; -; 1.
DR Gene3D; 2.70.170.10; -; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945; PTHR18945; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF63712; SSF63712; 1.
DR SUPFAM; SSF90112; SSF90112; 1.
PE 3: Inferred from homology;
KW Cell membrane; Glycoprotein; Ion channel; Ion transport;
KW Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor;
KW Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..598
FT /note="Acetylcholine receptor subunit alpha-type acr-5"
FT /id="PRO_0000000402"
FT TOPO_DOM 17..323
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 324..344
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 345..356
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 357..377
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 378..391
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 392..412
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 413..563
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 564..584
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 585..598
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT CARBOHYD 54
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 71
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 77
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 134
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 178
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 252
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 598 AA; 70234 MW; 9476C3C6EFE4257E CRC64;
MLPNIILILL IRYCSCGAGS RVYEKYGKQV QLSPATTSSY REWYDSNREH STRNNTNVDD
FQTQLKKSLE NTTAAYNATF MQELIEERQR YLEKLNEGQF INDQRRLVEE LLDPNYYEKT
VHPKRDYTRP TRVNLSMSLY QILDVDEHMQ SIEVNVWMVQ HWYDEFLDWN PVDYGMINRT
IVPYHQIWIP DTYLYNSEEL EQKKTESLMN AQLETGHWNQ KKDGAKVQLM FPAIYKLSCR
MDVRWFPYDR QNCTFIISSW THDKQTIDYW PLSSTVNLGN MARNDEWEVI SFEFVRVEET
FKCCTAPWVM LYAHLVIRRK PLYYMINLVV PTSIITIVAV TGFFTPTSSS SERDEKLYLG
INTLLTMSVM MLMVCNQMPS TSTYVPLMSW YYIGIIMVIV VGTFLATGVL AIHGQKHYNK
PISDRIRKLI YNPVVEFFIL SPPTSLIDLW TEFGVISEQR HSTHLDPLLL QHMDPISHTT
RADPQHFFGS ISSQMCDLQS TYSYTARLAT ITRQYTQHAK MKALRKNQYR MSMDTSQARG
VKKQKMQRRC SLEWEFLANV LDRILLTIFC GFTFAVFIIL IGFDSFFTFH TDSPPKTM
