ID   36014_ASFP4             Reviewed;         357 AA.
AC   P0C9Q7;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 28.
DE   RecName: Full=Protein MGF 360-14L;
GN   OrderedLocusNames=Pret-037;
OS   African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996)
OS   (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=561443;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=85517; Phacochoerus aethiopicus (Warthog).
OH   NCBI_TaxID=41426; Phacochoerus africanus (Warthog).
OH   NCBI_TaxID=273792; Potamochoerus larvatus (Bushpig).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Kutish G.F., Rock D.L.;
RT   "African swine fever virus genomes.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in virus cell tropism, and may be required for
CC       efficient virus replication in macrophages. Inhibits also the host
CC       cGAS/STING-mediated type I interferon production by inducing host IRF3
CC       degradation through the proteasome pathway. {ECO:0000250,
CC       ECO:0000250|UniProtKB:P0C9Q5}.
CC   -!- SUBUNIT: Interacts with host IRF3 and TRIM21; these interactions
CC       mediates degradation of IRF3 through TRIM21 and ubiquitin-meditated
CC       proteolysis. {ECO:0000250|UniProtKB:P0C9Q5}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250|UniProtKB:P0C9Q5}.
CC   -!- SIMILARITY: Belongs to the asfivirus MGF 360 family. {ECO:0000305}.
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DR   EMBL; AY261363; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Proteomes; UP000000859; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0039548; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity; IEA:UniProtKB-KW.
DR   GO; GO:0042330; P:taxis; IEA:InterPro.
DR   InterPro; IPR002595; ASFV_MGF360.
DR   Pfam; PF01671; ASFV_360; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host-virus interaction;
KW   Inhibition of host innate immune response by virus;
KW   Inhibition of host IRF3 by virus; Inhibition of host RLR pathway by virus;
KW   Viral immunoevasion.
FT   CHAIN           1..357
FT                   /note="Protein MGF 360-14L"
FT                   /id="PRO_0000373290"
SQ   SEQUENCE   357 AA;  41379 MW;  B6BBAE67313F0EA0 CRC64;
     MLSLQTLAKK VVACNYLSSD YDYTLQRFGL WWDLGPIHLC NNCKQIFSYK HLQCFSEDDL
     CLEAALVKAV KSDNLELIRL FVDWGANPEY GLIRVPAVHL KRLCTELGGL TPVTEPRLLE
     ILKEVAKLKS CAGVLLGYDM FCHNPLLETV TRTTLDTVTY TCSNIPLTGD TAHLLLTKFW
     FALALRHNFT KAIHYFYKRH KNHLYWRVAC SLYFNNIFDI HELCREKEIC ISPNLMMKFA
     CLQKKNYAAI YYCYRLGASL DYGMNLSIYN NNTLNMFFCI DLGATDFDRA QHIAHKAYMY
     NLSNIFLVKQ LFSRDVTLAL DVTEPQEIYD RLKSYTSKNL KRAEEYLTAH PEIIVID