ID   ACRB_ASPFC              Reviewed;        1019 AA.
AC   B0Y4N5;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Probable ubiquitination network signaling protein acrB;
DE   AltName: Full=Acriflavine resistance protein B;
GN   Name=acrB; Synonyms=acr2; ORFNames=AFUB_069710;
OS   Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus
OS   fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=451804;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CEA10 / CBS 144.89 / FGSC A1163;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Component of the regulatory network controlling carbon source
CC       utilization through ubiquitination and deubiquitination involving creA,
CC       creB, creC, creD and acrB. Involved in resistance to acriflavine, and
CC       required for normal growth on a range of sole carbon sources, including
CC       fructose, cellobiose, raffinose, and starch, and reduced utilization of
CC       amino acids, including GABA and beta-alanine, as sole carbon and
CC       nitrogen sources (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the acrB family. {ECO:0000305}.
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DR   EMBL; DS499598; EDP50634.1; -; Genomic_DNA.
DR   AlphaFoldDB; B0Y4N5; -.
DR   SMR; B0Y4N5; -.
DR   EnsemblFungi; EDP50634; EDP50634; AFUB_069710.
DR   HOGENOM; CLU_005822_0_0_1; -.
DR   PhylomeDB; B0Y4N5; -.
DR   Proteomes; UP000001699; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   PROSITE; PS00589; PTS_HPR_SER; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Transmembrane; Transmembrane helix;
KW   Ubl conjugation pathway.
FT   CHAIN           1..1019
FT                   /note="Probable ubiquitination network signaling protein
FT                   acrB"
FT                   /id="PRO_0000395727"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        259..279
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          109..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          343..372
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          580..603
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          831..855
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          879..905
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          963..1019
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          602..788
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        17..85
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        965..1019
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1019 AA;  109735 MW;  C221657780D072BA CRC64;
     MPRSSATARK SHSNRHENGS ANTGKKVAKQ KSNGHLNGNL NGGSASSSLS SSQVDLPSSR
     SSSDPVVPTT TAASTKLNGT PDSSKGDCNA PDHLNGYAKG NADMSYVQND GVASQTGGDV
     AGPASRRTEK SATGSKRSPS NASVNPLQLA STILKSCPMY DTIAILIFLL QLPPMVLTLV
     QFLFASLTFL PPSGASAGSL TSNFDIFQGP AGTPSLGTMI AMDGFCLLIW GLFMWTWAQN
     FALDLAHVQV AITLGGGGFG KNGGVNTLCV GIVLIMHLVR SKGIQDFVIG HLLSSNIISP
     DMLSQYSHLL PTEFRRTEPQ TSPSWLRSLL AVHILAQAGT AMARRSMAKN RTPNPPRTGK
     RIDTEASAGS QTQIDSAFES GASVSSYIGA DGQIVTSAAH KDGRDRLLSA KKRRRQANQV
     RSRQPFWAAL ASTKITVMRE YEHSRALSKT ARSLPMTEDD LQGLSLDDGL VWITEIDSST
     IKFAAGDFSS ADDSSGSGAC EAGCLGSEDM EPFYVCVNGA LWATATICKV HDAPKGSSMV
     HWRGEISGLA PNCAYTCSFV RSDTDEEICV ISVKTPANND AEQVSSVSTP PHPSYRPSSP
     TTTLKNSIVN AEAKLNEKRS RLRKAKNDHK LIISKIRKEL DNYNHRLHSG TDENRQKQRS
     LQLERNIRQT EEATALLEDQ LDNLENVPEE ELRKWSDQKA KYEHELGLLN SAKEELASAR
     SAIAREVSSL ETELSSAIQR RERLQSRRTR INEQYERIVS ANAQGLNERE RRAAEQFARE
     QDQAKLEATF NEQFATIGQS VQEYQLRAQQ IWQQCDAIEQ AIQQQHQQML LDPGPLTPEG
     NLPGTNPFSE SALPLGALTS TAPSSRSLLG LSFPPLKSSP LQTASSPVGA SSSHPTSPVQ
     QPSYLNFPTS PLVNASSHLD SDFVYRHRSF SNRSARSSLY GSDFMDSSRR QPFQLDLSEL
     LADKRSPGSD SNTALNSGLR PVSSPFQRAG SRGSGSGSNG SGGSGSGSGS PSSVYGKTN