ID   36014_ASFWA             Reviewed;         357 AA.
AC   P0C9Q5;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 25.
DE   RecName: Full=Protein MGF 360-14L;
GN   OrderedLocusNames=War-035;
OS   African swine fever virus (isolate Warthog/Namibia/Wart80/1980) (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=561444;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=85517; Phacochoerus aethiopicus (Warthog).
OH   NCBI_TaxID=41426; Phacochoerus africanus (Warthog).
OH   NCBI_TaxID=273792; Potamochoerus larvatus (Bushpig).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Kutish G.F., Rock D.L.;
RT   "African swine fever virus genomes.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, INTERACTION WITH HOST IRF3, AND SUBCELLULAR LOCATION.
RX   PubMed=35096660; DOI=10.3389/fcimb.2021.818969;
RA   Wang Y., Cui S., Xin T., Wang X., Yu H., Chen S., Jiang Y., Gao X.,
RA   Jiang Y., Guo X., Jia H., Zhu H.;
RT   "African Swine Fever Virus MGF360-14L Negatively Regulates Type I
RT   Interferon Signaling by Targeting IRF3.";
RL   Front. Cell. Infect. Microbiol. 11:818969-818969(2021).
CC   -!- FUNCTION: Plays a role in virus cell tropism, and may be required for
CC       efficient virus replication in macrophages. Inhibits also the host
CC       cGAS/STING-mediated type I interferon production by inducing host IRF3
CC       degradation through the proteasome pathway.
CC       {ECO:0000269|PubMed:35096660}.
CC   -!- SUBUNIT: Interacts with host IRF3 and TRIM21; these interactions
CC       mediates degradation of IRF3 through TRIM21 and ubiquitin-meditated
CC       proteolysis. {ECO:0000269|PubMed:35096660}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000269|PubMed:35096660}.
CC   -!- SIMILARITY: Belongs to the asfivirus MGF 360 family. {ECO:0000305}.
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DR   EMBL; AY261366; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Proteomes; UP000000858; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0039548; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity; IEA:UniProtKB-KW.
DR   GO; GO:0042330; P:taxis; IEA:InterPro.
DR   InterPro; IPR002595; ASFV_MGF360.
DR   Pfam; PF01671; ASFV_360; 1.
PE   1: Evidence at protein level;
KW   Host cytoplasm; Host-virus interaction;
KW   Inhibition of host innate immune response by virus;
KW   Inhibition of host IRF3 by virus; Inhibition of host RLR pathway by virus;
KW   Viral immunoevasion.
FT   CHAIN           1..357
FT                   /note="Protein MGF 360-14L"
FT                   /id="PRO_0000373288"
SQ   SEQUENCE   357 AA;  41471 MW;  CD17CF073A7A260B CRC64;
     MLSLQTLAKK VVACNYLSSD YDYMLQRFGL WWDLGPIHLC NNCKQIFSYK HLQCFSEDDL
     CLEAALVKAV KSDNLELIRL FVDWGANPEY GLIRVPAVHL KRLCTELGGL TPVSEPRLLE
     ILKEVAKLKS CAGVLLGYDM FCHNPLLETV TRTTLDTVTY TCSNIPLTGD TAHHLLTKFW
     FALALRHNFT KAIHYFYKRH KNHLYWRVAC SLYFNNIFDI HELCREKEIC ISPNLMMKFA
     CLRKKNYAAI YYCYRLGASL DYGMNLSIYN NNTLNMFFCI DLGATDFDRA QRIAHKTYMY
     NLSNIFLVKQ LFSRDVTLAL DVTEPQEIYD MLKSYTSKNL KRAEEYLTAH PEIIVID