ID   ACRB_ASPOR              Reviewed;        1013 AA.
AC   Q2UUI0;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   13-JUL-2010, sequence version 2.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Probable ubiquitination network signaling protein acrB;
DE   AltName: Full=Acriflavine resistance protein B;
GN   Name=acrB; Synonyms=acr2; ORFNames=AO090009000307;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: Component of the regulatory network controlling carbon source
CC       utilization through ubiquitination and deubiquitination involving creA,
CC       creB, creC, creD and acrB. Involved in resistance to acriflavine, and
CC       required for normal growth on a range of sole carbon sources, including
CC       fructose, cellobiose, raffinose, and starch, and reduced utilization of
CC       amino acids, including GABA and beta-alanine, as sole carbon and
CC       nitrogen sources (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the acrB family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAE54785.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP007150; BAE54785.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; Q2UUI0; -.
DR   SMR; Q2UUI0; -.
DR   STRING; 510516.Q2UUI0; -.
DR   EnsemblFungi; BAE54785; BAE54785; AO090009000307.
DR   VEuPathDB; FungiDB:AO090009000307; -.
DR   Proteomes; UP000006564; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   PROSITE; PS00589; PTS_HPR_SER; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Ubl conjugation pathway.
FT   CHAIN           1..1013
FT                   /note="Probable ubiquitination network signaling protein
FT                   acrB"
FT                   /id="PRO_0000395730"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        254..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          105..137
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          339..367
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          875..902
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          953..1013
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          596..782
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        108..137
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        991..1013
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1013 AA;  109286 MW;  6967670D69EFE933 CRC64;
     MPRSSATARK SHSNRQENGA AGSGKKVNKQ KSNGQLNGNA NGSSAPISGP SSQVDWPSSR
     SNSDTAINST VATATKANGT TECSKADGNG RGYLNGYVKG NPDMSYGQAN GAVPQNGGLT
     GQASRRTESS KRSGSNTSIN PLQLASTILK SCPMYDTIAI LIFLLQLPPM VLTLVQFLFA
     SLTFMPPGGA SAGSLTSNFD IFQGPAGTPS LGTMIAMDGF FLLFWGLFMW TWAQNFALDL
     AHVQVAITLG GGGSGKNGGV NTLCVGIVLV LHLIRSKGIQ DFVLGHLLSA KVISPDLLSQ
     YSHLLPSEFR RTEPQSSPSW IRSLLAVHIL AQAGTAMARR SMAKNRAPAP PRTGKRVDTE
     ASAGSQTQID SAFESGTSVS SYIGADGQLI TPATHKDGRD RLISAKKRRR QANQVRNRQP
     FWAALASTKV TVMREYEHSR ALSKTARGLT MTEEDLQGVS LDDGLVWITD VDSSSIKFAA
     GDLVSEDAGV SGSCESGRLG EDMEPFYVCV NGALWATVTI CKVQDVAKGS SVVHWRGEIS
     GLAPNCAYTC SFLRSDTEEE ICVMSVKTPI ANDAEQVVSS VSTPPQPSYR PSSPTTTLKN
     SIVNAELKLN EKRTRLRKAK NDHKLVVSKI RKELDNYNHR LHSGTDENRQ KQRSLQLERN
     IKQTEEATAV LEVQLDNLEN IPEEELEEWS AEKAKYEHEL ELFNSAKEDV ATARSAAARE
     VSQLESDLTS TIQRRERLQG RRTRVNEQYE RIISANAQGL NERERRAAEQ FAREQDQAKV
     EANFNEQFAS ISQSVQEYQL RTNQLWQQCV AIEQALQQQQ QQQILLDSAP LTPEGNLPGT
     NTLSEAPTLS LGALTTSASS NRSLLGLSFP PLKSSPLQHA SSPIGPTSSR PTSPTQAPSY
     LQHFPASPLI NTASPFESDF IHRDRSFSNR SGHSSLYGSD FFDSGRRPPF QFDLSEKVVD
     KRRSSGSESN APNLGLRPIC SPFPRAGSRA SGSGSGGSGS GSGSPSSATG KGN