ID   ACRB_NEOFI              Reviewed;        1019 AA.
AC   A1CW63;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Probable ubiquitination network signaling protein acrB;
DE   AltName: Full=Acriflavine resistance protein B;
GN   Name=acrB; Synonyms=acr2; ORFNames=NFIA_103530;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC   / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Component of the regulatory network controlling carbon source
CC       utilization through ubiquitination and deubiquitination involving creA,
CC       creB, creC, creD and acrB. Involved in resistance to acriflavine, and
CC       required for normal growth on a range of sole carbon sources, including
CC       fructose, cellobiose, raffinose, and starch, and reduced utilization of
CC       amino acids, including GABA and beta-alanine, as sole carbon and
CC       nitrogen sources (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the acrB family. {ECO:0000305}.
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DR   EMBL; DS027685; EAW24865.1; -; Genomic_DNA.
DR   RefSeq; XP_001266762.1; XM_001266761.1.
DR   AlphaFoldDB; A1CW63; -.
DR   SMR; A1CW63; -.
DR   STRING; 36630.CADNFIAP00009287; -.
DR   EnsemblFungi; EAW24865; EAW24865; NFIA_103530.
DR   GeneID; 4593362; -.
DR   KEGG; nfi:NFIA_103530; -.
DR   VEuPathDB; FungiDB:NFIA_103530; -.
DR   eggNOG; ENOG502QSPS; Eukaryota.
DR   HOGENOM; CLU_005822_0_0_1; -.
DR   OMA; SDEVCFN; -.
DR   OrthoDB; 225448at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   PROSITE; PS00589; PTS_HPR_SER; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Ubl conjugation pathway.
FT   CHAIN           1..1019
FT                   /note="Probable ubiquitination network signaling protein
FT                   acrB"
FT                   /id="PRO_0000395733"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        259..279
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..142
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          343..372
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          580..603
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          831..859
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          879..905
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          963..1019
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          602..788
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        17..85
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        101..116
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        842..859
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        965..1019
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1019 AA;  109756 MW;  F72A1FEED27F5980 CRC64;
     MPRSSATARK SHSNRHENGS ANTGKKVAKQ KSNGHLNGNL NGGSASSSLS SSQVDLPSSR
     SSSDPVIPTT TATSTKLNGT PDSSKGDCNA PDHLNGYAKG NTDMSYVQNN GVASQTGGDV
     AGPASRRTEK SATGNKRSPS NASINPLQLA STILKSCPMY DTIAILIFLL QLPPMVLTLV
     QFLFASLTFL PPSGASAGSL TSNFDIFQGP AGTPSLGTMI AMDGFCLLIW GLFMWTWAQN
     FALDLAHVQV AITLGGGGFG KNGGVNTLCV GIVLIMHLVR SKGIQDFVIG HLLSSNIISP
     DMLSQYSHLL PTEFRRTEPQ TSPSWLRSLL AVHILAQAGT AMARRSMAKN RTPNPPRTGK
     RIDTEASAGS QTQIDSAFES GASVSSYIGA DGQIVTPAAH KDGRDRLLSA KKRRRQANQV
     RSRQPFWAAL ASTKITVMRE YEHSRALSKT ARGLPMTEDD LQGLSLDDGL VWITEIDSST
     IKFAAGDFSS ADDSSGSGAC EAGCLGSEDM EPFYVCVNGA LWATATICKV HDAPKGSSMV
     HWRGEISGLA PNCAYTCSFV RSDTDEEICV ISVKTPATND AEQVSSVSTP PQPSYRPSSP
     TTTLKNSIVN AEAKLNEKRS RLRKAKNDHK LVISKIRKEL DNYNHRLHSG TDENRQKQRS
     LQLERNIRQT EEATALLEDQ LDNLENVPDE ELRKWSDQKA KYEHELGLLN SAKEELASAR
     SAVAREVSSL ETELSSAIQR RERLQSRRTR INEQYERIVS ANAQGLNERE RRAAEQFARE
     QDQAKLEATF NEQFASIGQS VQEYQLRAQQ IWQQCDAIEQ AIQQQHQQML LDPGPLTPEG
     NLPGTNPFSE SALPLGALTS TAPSNRSLLG LSFPPLKSSP LQTASSPVGA SSSHPTSPVQ
     QPSYLNFPTS PLVNASSHLD SDFVYRDRSF SNRSARSSLY GSDFMDSSRR QPFQLDLSEL
     LADKRSPGSD SNTALNSGLR PVSSPFQRAG SRGSGSGSNG SGGSGSGSGS PSSVYGKTN