ID   ACRR_ECOL6              Reviewed;         215 AA.
AC   P0ACT0; P34000;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=HTH-type transcriptional regulator AcrR;
DE   AltName: Full=Potential acrAB operon repressor;
GN   Name=acrR; OrderedLocusNames=c0582;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Potential regulator protein for the acrAB genes.
CC       {ECO:0000250}.
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DR   EMBL; AE014075; AAN79060.1; -; Genomic_DNA.
DR   RefSeq; WP_000101737.1; NC_004431.1.
DR   AlphaFoldDB; P0ACT0; -.
DR   SMR; P0ACT0; -.
DR   STRING; 199310.c0582; -.
DR   PRIDE; P0ACT0; -.
DR   EnsemblBacteria; AAN79060; AAN79060; c0582.
DR   GeneID; 66671234; -.
DR   KEGG; ecc:c0582; -.
DR   eggNOG; COG1309; Bacteria.
DR   HOGENOM; CLU_069356_12_3_6; -.
DR   OMA; MMEIIFH; -.
DR   BioCyc; ECOL199310:C0582-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   InterPro; IPR013572; Tscrpt_reg_MAATS_C.
DR   Pfam; PF08361; TetR_C_2; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..215
FT                   /note="HTH-type transcriptional regulator AcrR"
FT                   /id="PRO_0000070574"
FT   DOMAIN          10..70
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        33..52
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   215 AA;  24767 MW;  CB002F8DC1F682BB CRC64;
     MARKTKQEAQ ETRQHILDVA LRLFSQQGVS STSLGEIAKA AGVTRGAIYW HFKDKSDLFS
     EIWELSESNI GELELEYQAK FPGDPLSVLR EILIHVLEST VTEERRRLLM EIIFHKCEFV
     GEMAVVQQAQ RNLCLESYDR IEQTLKHCIE AKMLPADLMT RRAAIIMRGY ISGLMENWLF
     APQSFDLKKE ARDYVAILLE MYLLCPTLRN PATNE