ACRR_ECOLI
ID ACRR_ECOLI Reviewed; 215 AA.
AC P0ACS9; P34000; Q2MBW3;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=HTH-type transcriptional regulator AcrR;
DE AltName: Full=Potential acrAB operon repressor;
GN Name=acrR; Synonyms=ybaH; OrderedLocusNames=b0464, JW0453;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12 / W4573;
RX PubMed=8407802; DOI=10.1128/jb.175.19.6299-6313.1993;
RA Ma D., Cook D.N., Alberti M., Pon N.G., Nikaido H., Hearst J.E.;
RT "Molecular cloning and characterization of acrA and acrE genes of
RT Escherichia coli.";
RL J. Bacteriol. 175:6299-6313(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RA Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT "Sequence of minutes 4-25 of Escherichia coli.";
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP IDENTIFICATION.
RA Rudd K.E.;
RL Unpublished observations (DEC-1993).
CC -!- FUNCTION: Potential regulator protein for the acrAB genes.
CC -!- INTERACTION:
CC P0ACS9; P76215: astE; NbExp=3; IntAct=EBI-1117360, EBI-1121806;
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DR EMBL; U00734; AAA67133.1; -; Genomic_DNA.
DR EMBL; U82664; AAB40218.1; -; Genomic_DNA.
DR EMBL; U00096; AAC73566.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76243.1; -; Genomic_DNA.
DR PIR; G64776; G64776.
DR RefSeq; NP_414997.1; NC_000913.3.
DR RefSeq; WP_000101737.1; NZ_STEB01000007.1.
DR PDB; 2QOP; X-ray; 2.55 A; A=1-215.
DR PDB; 3BCG; X-ray; 2.48 A; A/B=1-215.
DR PDBsum; 2QOP; -.
DR PDBsum; 3BCG; -.
DR AlphaFoldDB; P0ACS9; -.
DR SMR; P0ACS9; -.
DR BioGRID; 4260988; 9.
DR BioGRID; 849890; 19.
DR IntAct; P0ACS9; 18.
DR STRING; 511145.b0464; -.
DR jPOST; P0ACS9; -.
DR PaxDb; P0ACS9; -.
DR PRIDE; P0ACS9; -.
DR EnsemblBacteria; AAC73566; AAC73566; b0464.
DR EnsemblBacteria; BAE76243; BAE76243; BAE76243.
DR GeneID; 66671234; -.
DR GeneID; 945516; -.
DR KEGG; ecj:JW0453; -.
DR KEGG; eco:b0464; -.
DR PATRIC; fig|1411691.4.peg.1812; -.
DR EchoBASE; EB2039; -.
DR eggNOG; COG1309; Bacteria.
DR HOGENOM; CLU_069356_12_3_6; -.
DR InParanoid; P0ACS9; -.
DR OMA; MMEIIFH; -.
DR PhylomeDB; P0ACS9; -.
DR BioCyc; EcoCyc:EG12116-MON; -.
DR EvolutionaryTrace; P0ACS9; -.
DR PRO; PR:P0ACS9; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:EcoCyc.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:EcoCyc.
DR GO; GO:0015643; F:toxic substance binding; IDA:EcoCyc.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:EcoCyc.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:EcoCyc.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IDA:EcoCyc.
DR InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR InterPro; IPR013572; Tscrpt_reg_MAATS_C.
DR Pfam; PF08361; TetR_C_2; 1.
DR Pfam; PF00440; TetR_N; 1.
DR PRINTS; PR00455; HTHTETR.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF48498; SSF48498; 1.
DR PROSITE; PS01081; HTH_TETR_1; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..215
FT /note="HTH-type transcriptional regulator AcrR"
FT /id="PRO_0000070573"
FT DOMAIN 10..70
FT /note="HTH tetR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT DNA_BIND 33..52
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT HELIX 9..27
FT /evidence="ECO:0007829|PDB:3BCG"
FT TURN 28..31
FT /evidence="ECO:0007829|PDB:2QOP"
FT HELIX 34..41
FT /evidence="ECO:0007829|PDB:3BCG"
FT HELIX 45..51
FT /evidence="ECO:0007829|PDB:3BCG"
FT STRAND 53..55
FT /evidence="ECO:0007829|PDB:3BCG"
FT HELIX 56..64
FT /evidence="ECO:0007829|PDB:3BCG"
FT HELIX 74..77
FT /evidence="ECO:0007829|PDB:3BCG"
FT TURN 78..80
FT /evidence="ECO:0007829|PDB:3BCG"
FT STRAND 81..83
FT /evidence="ECO:0007829|PDB:3BCG"
FT HELIX 86..102
FT /evidence="ECO:0007829|PDB:3BCG"
FT HELIX 104..115
FT /evidence="ECO:0007829|PDB:3BCG"
FT TURN 121..124
FT /evidence="ECO:0007829|PDB:3BCG"
FT HELIX 125..150
FT /evidence="ECO:0007829|PDB:3BCG"
FT HELIX 162..180
FT /evidence="ECO:0007829|PDB:3BCG"
FT TURN 182..184
FT /evidence="ECO:0007829|PDB:2QOP"
FT HELIX 187..204
FT /evidence="ECO:0007829|PDB:3BCG"
FT STRAND 206..208
FT /evidence="ECO:0007829|PDB:3BCG"
SQ SEQUENCE 215 AA; 24767 MW; CB002F8DC1F682BB CRC64;
MARKTKQEAQ ETRQHILDVA LRLFSQQGVS STSLGEIAKA AGVTRGAIYW HFKDKSDLFS
EIWELSESNI GELELEYQAK FPGDPLSVLR EILIHVLEST VTEERRRLLM EIIFHKCEFV
GEMAVVQQAQ RNLCLESYDR IEQTLKHCIE AKMLPADLMT RRAAIIMRGY ISGLMENWLF
APQSFDLKKE ARDYVAILLE MYLLCPTLRN PATNE
