ACRR_SHIFL
ID ACRR_SHIFL Reviewed; 215 AA.
AC P0ACT1; P34000;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=HTH-type transcriptional regulator AcrR;
DE AltName: Full=Potential acrAB operon repressor;
GN Name=acrR; OrderedLocusNames=SF0409, S0416;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Potential regulator protein for the acrAB genes.
CC {ECO:0000250}.
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DR EMBL; AE005674; AAN42064.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP15941.1; -; Genomic_DNA.
DR RefSeq; NP_706357.1; NC_004337.2.
DR RefSeq; WP_000101737.1; NZ_WPGW01000015.1.
DR AlphaFoldDB; P0ACT1; -.
DR SMR; P0ACT1; -.
DR STRING; 198214.SF0409; -.
DR EnsemblBacteria; AAN42064; AAN42064; SF0409.
DR EnsemblBacteria; AAP15941; AAP15941; S0416.
DR GeneID; 1027719; -.
DR GeneID; 66671234; -.
DR KEGG; sfl:SF0409; -.
DR KEGG; sfx:S0416; -.
DR PATRIC; fig|198214.7.peg.469; -.
DR HOGENOM; CLU_069356_12_3_6; -.
DR OMA; MMEIIFH; -.
DR OrthoDB; 2047542at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR InterPro; IPR013572; Tscrpt_reg_MAATS_C.
DR Pfam; PF08361; TetR_C_2; 1.
DR Pfam; PF00440; TetR_N; 1.
DR PRINTS; PR00455; HTHTETR.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF48498; SSF48498; 1.
DR PROSITE; PS01081; HTH_TETR_1; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..215
FT /note="HTH-type transcriptional regulator AcrR"
FT /id="PRO_0000070575"
FT DOMAIN 10..70
FT /note="HTH tetR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT DNA_BIND 33..52
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ SEQUENCE 215 AA; 24767 MW; CB002F8DC1F682BB CRC64;
MARKTKQEAQ ETRQHILDVA LRLFSQQGVS STSLGEIAKA AGVTRGAIYW HFKDKSDLFS
EIWELSESNI GELELEYQAK FPGDPLSVLR EILIHVLEST VTEERRRLLM EIIFHKCEFV
GEMAVVQQAQ RNLCLESYDR IEQTLKHCIE AKMLPADLMT RRAAIIMRGY ISGLMENWLF
APQSFDLKKE ARDYVAILLE MYLLCPTLRN PATNE
