ID   ACRZ_ECO57              Reviewed;          49 AA.
AC   P0AAX1; P75759;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Multidrug efflux pump accessory protein AcrZ {ECO:0000255|HAMAP-Rule:MF_01484};
DE   AltName: Full=AcrAB-TolC multidrug efflux pump accessory protein AcrZ {ECO:0000255|HAMAP-Rule:MF_01484};
DE   AltName: Full=Acridine resistance protein Z {ECO:0000255|HAMAP-Rule:MF_01484};
GN   Name=acrZ {ECO:0000255|HAMAP-Rule:MF_01484};
GN   OrderedLocusNames=Z0932, ECs0790;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a
CC       broad substrate specificity. This protein binds to AcrB and is required
CC       for efflux of some but not all substrates, suggesting it may influence
CC       the specificity of drug export. {ECO:0000255|HAMAP-Rule:MF_01484}.
CC   -!- SUBUNIT: Part of the AcrA-AcrB-AcrZ-TolC efflux pump, interacts
CC       directly with AcrB. {ECO:0000255|HAMAP-Rule:MF_01484}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01484}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01484}.
CC   -!- SIMILARITY: Belongs to the AcrZ family. {ECO:0000255|HAMAP-
CC       Rule:MF_01484}.
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DR   EMBL; AE005174; AAG55091.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB34213.1; -; Genomic_DNA.
DR   PIR; F90727; F90727.
DR   PIR; G85578; G85578.
DR   RefSeq; NP_308817.1; NC_002695.1.
DR   RefSeq; WP_000891515.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0AAX1; -.
DR   SMR; P0AAX1; -.
DR   STRING; 155864.EDL933_0836; -.
DR   EnsemblBacteria; AAG55091; AAG55091; Z0932.
DR   EnsemblBacteria; BAB34213; BAB34213; ECs_0790.
DR   GeneID; 67413801; -.
DR   GeneID; 917527; -.
DR   KEGG; ece:Z0932; -.
DR   KEGG; ecs:ECs_0790; -.
DR   PATRIC; fig|386585.9.peg.910; -.
DR   eggNOG; ENOG5033AHW; Bacteria.
DR   HOGENOM; CLU_196028_0_1_6; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR   HAMAP; MF_01484; AcrZ; 1.
DR   InterPro; IPR019702; AcrZ.
DR   Pfam; PF10766; AcrZ; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell inner membrane; Cell membrane; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..49
FT                   /note="Multidrug efflux pump accessory protein AcrZ"
FT                   /id="PRO_0000042561"
FT   TOPO_DOM        1..7
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01484"
FT   TOPO_DOM        29..49
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   49 AA;  5300 MW;  1B1185D27F1F37F7 CRC64;
     MLELLKSLVF AVIMVPVVMA IILGLIYGLG EVFNIFSGVG KKDQPGQNH