ACRZ_ECOL6
ID ACRZ_ECOL6 Reviewed; 49 AA.
AC P0AAX0; P75759;
DT 11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Multidrug efflux pump accessory protein AcrZ {ECO:0000255|HAMAP-Rule:MF_01484};
DE AltName: Full=AcrAB-TolC multidrug efflux pump accessory protein AcrZ {ECO:0000255|HAMAP-Rule:MF_01484};
DE AltName: Full=Acridine resistance protein Z {ECO:0000255|HAMAP-Rule:MF_01484};
GN Name=acrZ {ECO:0000255|HAMAP-Rule:MF_01484}; Synonyms=ybhT;
GN OrderedLocusNames=c0838;
OS Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=199310;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFT073 / ATCC 700928 / UPEC;
RX PubMed=12471157; DOI=10.1073/pnas.252529799;
RA Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA Donnenberg M.S., Blattner F.R.;
RT "Extensive mosaic structure revealed by the complete genome sequence of
RT uropathogenic Escherichia coli.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC -!- FUNCTION: AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a
CC broad substrate specificity. This protein binds to AcrB and is required
CC for efflux of some but not all substrates, suggesting it may influence
CC the specificity of drug export. {ECO:0000255|HAMAP-Rule:MF_01484}.
CC -!- SUBUNIT: Part of the AcrA-AcrB-AcrZ-TolC efflux pump, interacts
CC directly with AcrB. {ECO:0000255|HAMAP-Rule:MF_01484}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01484}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01484}.
CC -!- SIMILARITY: Belongs to the AcrZ family. {ECO:0000255|HAMAP-
CC Rule:MF_01484}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN79311.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE014075; AAN79311.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_000891515.1; NC_004431.1.
DR AlphaFoldDB; P0AAX0; -.
DR SMR; P0AAX0; -.
DR STRING; 199310.c0838; -.
DR EnsemblBacteria; AAN79311; AAN79311; c0838.
DR GeneID; 67413801; -.
DR KEGG; ecc:c0838; -.
DR eggNOG; ENOG5033AHW; Bacteria.
DR HOGENOM; CLU_196028_0_1_6; -.
DR Proteomes; UP000001410; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR HAMAP; MF_01484; AcrZ; 1.
DR InterPro; IPR019702; AcrZ.
DR Pfam; PF10766; AcrZ; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance; Cell inner membrane; Cell membrane; Membrane;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..49
FT /note="Multidrug efflux pump accessory protein AcrZ"
FT /id="PRO_0000042562"
FT TOPO_DOM 1..7
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01484"
FT TOPO_DOM 29..49
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
SQ SEQUENCE 49 AA; 5300 MW; 1B1185D27F1F37F7 CRC64;
MLELLKSLVF AVIMVPVVMA IILGLIYGLG EVFNIFSGVG KKDQPGQNH
