ACRZ_SHIFL
ID ACRZ_SHIFL Reviewed; 49 AA.
AC P0AAX2; P75759;
DT 11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Multidrug efflux pump accessory protein AcrZ {ECO:0000255|HAMAP-Rule:MF_01484};
DE AltName: Full=AcrAB-TolC multidrug efflux pump accessory protein AcrZ {ECO:0000255|HAMAP-Rule:MF_01484};
DE AltName: Full=Acridine resistance protein Z {ECO:0000255|HAMAP-Rule:MF_01484};
GN Name=acrZ {ECO:0000255|HAMAP-Rule:MF_01484};
GN OrderedLocusNames=SF0542, S0550;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a
CC broad substrate specificity. This protein binds to AcrB and is required
CC for efflux of some but not all substrates, suggesting it may influence
CC the specificity of drug export. {ECO:0000255|HAMAP-Rule:MF_01484}.
CC -!- SUBUNIT: Part of the AcrA-AcrB-AcrZ-TolC efflux pump, interacts
CC directly with AcrB. {ECO:0000255|HAMAP-Rule:MF_01484}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01484}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01484}.
CC -!- SIMILARITY: Belongs to the AcrZ family. {ECO:0000255|HAMAP-
CC Rule:MF_01484}.
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DR EMBL; AE005674; AAN42186.2; -; Genomic_DNA.
DR EMBL; AE014073; AAP16059.1; -; Genomic_DNA.
DR RefSeq; NP_706479.2; NC_004337.2.
DR RefSeq; WP_000891515.1; NZ_WPGW01000046.1.
DR AlphaFoldDB; P0AAX2; -.
DR SMR; P0AAX2; -.
DR STRING; 198214.SF0542; -.
DR EnsemblBacteria; AAN42186; AAN42186; SF0542.
DR EnsemblBacteria; AAP16059; AAP16059; S0550.
DR GeneID; 1023485; -.
DR GeneID; 67413801; -.
DR KEGG; sfl:SF0542; -.
DR KEGG; sfx:S0550; -.
DR PATRIC; fig|198214.7.peg.631; -.
DR HOGENOM; CLU_196028_0_1_6; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR HAMAP; MF_01484; AcrZ; 1.
DR InterPro; IPR019702; AcrZ.
DR Pfam; PF10766; AcrZ; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance; Cell inner membrane; Cell membrane; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..49
FT /note="Multidrug efflux pump accessory protein AcrZ"
FT /id="PRO_0000042563"
FT TOPO_DOM 1..7
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01484"
FT TOPO_DOM 29..49
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
SQ SEQUENCE 49 AA; 5300 MW; 1B1185D27F1F37F7 CRC64;
MLELLKSLVF AVIMVPVVMA IILGLIYGLG EVFNIFSGVG KKDQPGQNH
