ID   ACS1_CANAX              Reviewed;         675 AA.
AC   O94049;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Acetyl-coenzyme A synthetase 1;
DE            EC=6.2.1.1;
DE   AltName: Full=Acetate--CoA ligase 1;
DE   AltName: Full=Acyl-activating enzyme 1;
GN   Name=ACS1; ORFNames=Ca38F10.03;
OS   Candida albicans (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=5476;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1161;
RA   Oliver K., Harris D., Barrell B.G., Rajandream M.A.;
RT   "Candida albicans strain 1161 genome pilot sequencing project.";
RL   Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate;
CC         Xref=Rhea:RHEA:23176, ChEBI:CHEBI:30089, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC         ChEBI:CHEBI:456215; EC=6.2.1.1;
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000305}.
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DR   EMBL; AL033502; CAA22000.1; -; Genomic_DNA.
DR   AlphaFoldDB; O94049; -.
DR   SMR; O94049; -.
DR   CGD; CAL0000184618; ACS1.
DR   VEuPathDB; FungiDB:C2_10350C_A; -.
DR   VEuPathDB; FungiDB:CAWG_06106; -.
DR   GO; GO:0005829; C:cytosol; ISA:CGD.
DR   GO; GO:0003987; F:acetate-CoA ligase activity; ISA:CGD.
DR   GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006085; P:acetyl-CoA biosynthetic process; ISA:CGD.
DR   GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; -; 1.
DR   InterPro; IPR011904; Ac_CoA_lig.
DR   InterPro; IPR032387; ACAS_N.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR042099; ANL_N_sf.
DR   Pfam; PF16177; ACAS_N; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   TIGRFAMs; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Ligase; Nucleotide-binding.
FT   CHAIN           1..675
FT                   /note="Acetyl-coenzyme A synthetase 1"
FT                   /id="PRO_0000208405"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         212..215
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000250"
FT   BINDING         331
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000250"
FT   BINDING         407..409
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         431..436
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         522
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         537
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         545
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000250"
FT   BINDING         548
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         609
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000250"
FT   VARIANT         504
FT                   /note="N -> K"
FT   VARIANT         543
FT                   /note="N -> D"
SQ   SEQUENCE   675 AA;  75100 MW;  32CD1F462F789B90 CRC64;
     MPESTQQSHL SLDHEKMQQP PKGFTERSKT KPNLADFETY QKLYKQSIEN PNEFFTQQAK
     ENLDWFKPFD LARFPVDPKD DYKNGDLPAW FINGQLNACY NAVDRWAIKN PDKPAIIYEG
     DEPDQGRIIT YGELLKQVSK LAQALTKLGV KKGDSVAVYL PMIPEAIVTL LAIVRIGAMH
     SVVFAGFSSA SLRDRILDAD SRIVITADES KRGGKTIETK KIVDDALKEC PKVRNVIVFK
     RTGNSHVPFS PGRDLWWHDE MAKYGPYFPP VPVNSEDPLF LLYTSGSTGK PKGVQHNTAG
     YLLGAVLTTK YTFDVHEDDI LFTAGDIGWI TGHTYCVYGP LLAGATSVVF EGTPAYPNYS
     RYWEIVDKYK VNQFYVAPTA LRLLKRAGTK YVEKYDLSSL RVLGSVGEPI AAEVWHWYND
     NIGRGQAHIV DTYWQTESGS HLLTPLAGIT PTKPGSASLP FFGVDPKILD PTTGEELPDN
     DVEGVLAIKS AWPSITRGIY NDYNRFIDTY LAPYANYYFS GDGAARDRDG FYWILGRVDD
     VVNVSGHRLS TAEIEAALIE HPIVGESAVV GYADELTGQA VAAYVSLKKD KAVGEDVENI
     KKEMILTVRK EIGPFAAPKM ILLVDDLPKT RSGKIMRRIL RKVLAGEEDQ LGDISTLSNP
     GVVQQIIDVV HHAKK