ID   ACS2_RUTGR              Reviewed;         391 AA.
AC   Q9FSC0;
DT   25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Acridone synthase 2;
DE            EC=2.3.1.159;
DE   AltName: Full=Acridone synthase II;
GN   Name=ACS2;
OS   Ruta graveolens (Common rue).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Sapindales; Rutaceae; Rutoideae; Ruta.
OX   NCBI_TaxID=37565;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND SUBUNIT.
RX   PubMed=10217426; DOI=10.1016/s0014-5793(99)00355-5;
RA   Lukacin R., Springob K., Urbanke C., Ernwein C., Schroeder G.,
RA   Schroeder J., Matern U.;
RT   "Native acridone synthases I and II from Ruta graveolens L. form
RT   homodimers.";
RL   FEBS Lett. 448:135-140(1999).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA = 1,3-
CC         dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O;
CC         Xref=Rhea:RHEA:22224, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:30306, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57384, ChEBI:CHEBI:58630; EC=2.3.1.159;
CC   -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:10217426}.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC       synthases family. {ECO:0000305}.
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DR   EMBL; AJ297788; CAC14058.1; -; mRNA.
DR   AlphaFoldDB; Q9FSC0; -.
DR   SMR; Q9FSC0; -.
DR   KEGG; ag:CAC14058; -.
DR   BioCyc; MetaCyc:MON-14039; -.
DR   BRENDA; 2.3.1.159; 5486.
DR   SABIO-RK; Q9FSC0; -.
DR   GO; GO:0050635; F:acridone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR   InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR   InterPro; IPR018088; Chalcone/stilbene_synthase_AS.
DR   InterPro; IPR011141; Polyketide_synthase_type-III.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11877; PTHR11877; 1.
DR   Pfam; PF02797; Chal_sti_synt_C; 1.
DR   Pfam; PF00195; Chal_sti_synt_N; 1.
DR   PIRSF; PIRSF000451; PKS_III; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   PROSITE; PS00441; CHALCONE_SYNTH; 1.
PE   1: Evidence at protein level;
KW   Acyltransferase; Flavonoid biosynthesis; Transferase.
FT   CHAIN           1..391
FT                   /note="Acridone synthase 2"
FT                   /id="PRO_0000216087"
FT   ACT_SITE        164
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10023"
SQ   SEQUENCE   391 AA;  42683 MW;  D553481BDA78457D CRC64;
     MESLKEMRKA QKSEGPAAIL AIGTATPDNV YIQADYPDYY FKITKSEHMT ELKDKFKTLC
     EKSMIRKRHM CFSQEFLKAN PEVCKHMGKS LNARQDIAVV ETPRIGKEAA VKAIKEWGHP
     KSSITHLIFC TSAGVDMPGA DYQLTRMLGL NPSVKRMMIY QQGCYAGGTV LRLAKDLAEN
     NKGSRVLVVC SELTAPTFRG PSPDAVDSLV GQALFADGAA ALVVGADPDT SVERALYYIV
     SASQMLLPDS DGAIEGHIRE EGLTVHLKKD VPALFSANID TPLVEAFRPL GISDWNSIFW
     IAHPGGPAIL DQIEVKLGLK EDKLRASKHV MSEYGNMSSS CVLFVLDEMR NKSLQDGKST
     TGEGLDWGVL FGFGPGLTVE TVVLRSVPVE A