ID   ACS3_RUTGR              Reviewed;         391 AA.
AC   Q9FSC2;
DT   25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Probable acridone synthase 3;
DE            EC=2.3.1.159;
DE   AltName: Full=Acridone synthase III;
GN   Name=ACS3;
OS   Ruta graveolens (Common rue).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Sapindales; Rutaceae; Rutoideae; Ruta.
OX   NCBI_TaxID=37565;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Immature flower;
RA   Springob K., Matern U.;
RL   Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA = 1,3-
CC         dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O;
CC         Xref=Rhea:RHEA:22224, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:30306, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57384, ChEBI:CHEBI:58630; EC=2.3.1.159;
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC       synthases family. {ECO:0000305}.
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DR   EMBL; AJ297786; CAC14056.2; -; mRNA.
DR   PIR; S60241; S60241.
DR   AlphaFoldDB; Q9FSC2; -.
DR   SMR; Q9FSC2; -.
DR   PRIDE; Q9FSC2; -.
DR   GO; GO:0050635; F:acridone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR   InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR   InterPro; IPR018088; Chalcone/stilbene_synthase_AS.
DR   InterPro; IPR011141; Polyketide_synthase_type-III.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11877; PTHR11877; 1.
DR   Pfam; PF02797; Chal_sti_synt_C; 1.
DR   Pfam; PF00195; Chal_sti_synt_N; 1.
DR   PIRSF; PIRSF000451; PKS_III; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   PROSITE; PS00441; CHALCONE_SYNTH; 1.
PE   2: Evidence at transcript level;
KW   Acyltransferase; Flavonoid biosynthesis; Transferase.
FT   CHAIN           1..391
FT                   /note="Probable acridone synthase 3"
FT                   /id="PRO_0000216088"
FT   ACT_SITE        164
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10023"
SQ   SEQUENCE   391 AA;  42726 MW;  C00A63095CEA8B93 CRC64;
     MESLKEMRKA QMSEGPAAIL AIGTANPDNV YMQADYPDYY FKMTKSEHMT ELKDKFRTLC
     EKSMIRKRHM CFSEEFLKAN PEVCKHMGKS LNARQDIAVV ETPRLGNEAA VKAIKEWGQP
     KSSITHLIFC SSAGVDMPGA DYQLTRILGL NPSVKRMMIY QQGCYAGGTV LRLAKDLAEN
     NKGSRVLVVC SELTAPTFRG PSPDAVDSLV GQALFADGAA ALVVGADPDS SIERALYYLV
     SASQMLLPDS DGAIEGHIRE EGLTVHLKKD VPALFSGNID TPLVEAFKPL GISDWNSIFW
     IAHPGGPAIL DQIEEKLGLK EDKLRASKHV MSEYGNMSSS CVLFVLDEMR SRSLQDGKST
     TGEGLDWGVL FGFGPGLTVE TIVLRSVPIE A