ID   ACS4_RUTGR              Reviewed;         391 AA.
AC   Q9FSC1;
DT   25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Probable acridone synthase 4;
DE            EC=2.3.1.159;
DE   AltName: Full=Acridone synthase IV;
GN   Name=ACS4;
OS   Ruta graveolens (Common rue).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Sapindales; Rutaceae; Rutoideae; Ruta.
OX   NCBI_TaxID=37565;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Immature flower;
RA   Springob K., Matern U.;
RL   Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA = 1,3-
CC         dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O;
CC         Xref=Rhea:RHEA:22224, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:30306, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57384, ChEBI:CHEBI:58630; EC=2.3.1.159;
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC       synthases family. {ECO:0000305}.
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DR   EMBL; AJ297787; CAC14057.1; -; mRNA.
DR   AlphaFoldDB; Q9FSC1; -.
DR   SMR; Q9FSC1; -.
DR   GO; GO:0050635; F:acridone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR   InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR   InterPro; IPR018088; Chalcone/stilbene_synthase_AS.
DR   InterPro; IPR011141; Polyketide_synthase_type-III.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11877; PTHR11877; 1.
DR   Pfam; PF02797; Chal_sti_synt_C; 1.
DR   Pfam; PF00195; Chal_sti_synt_N; 1.
DR   PIRSF; PIRSF000451; PKS_III; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   PROSITE; PS00441; CHALCONE_SYNTH; 1.
PE   2: Evidence at transcript level;
KW   Acyltransferase; Flavonoid biosynthesis; Transferase.
FT   CHAIN           1..391
FT                   /note="Probable acridone synthase 4"
FT                   /id="PRO_0000216089"
FT   ACT_SITE        164
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10023"
SQ   SEQUENCE   391 AA;  42710 MW;  DA6453B857D4C87B CRC64;
     MESLKEMRKA QMSEGPAAIL AIGTATPNNV YMQADYPDYY FRMTKSEHMT ELKDKFRTLC
     EKSMIRKRHM CFSEEFLKAN PEVSKHMGKS LNARQDIAVV ETPRLGNEAA VKAIKEWGQP
     KSSITHLIFC SSAGVDMPGA DYQLTRILGL NPSVKRMMVY QQGCYAGGTV LRLAKDLAEN
     NKGSRVLVVC SELTAPTFRG PSPDAVDSLV GQALFADGAA ALVVGADPDS SIERALYYLV
     SASQMLLPDS DGAIEGHIRE EGLTVHLKKD VPALFSANID TPLVEAFKPL GISDWNSIFW
     IAHPGGPAIL DQIEEKLGLK EDKLRASKHV MSEYGNMSSS CVLFVLDEMR SRSLQDGKST
     TGEGLDWGVL FGFGPGLTVE TVVLRSVPIE A