ACS4_RUTGR
ID ACS4_RUTGR Reviewed; 391 AA.
AC Q9FSC1;
DT 25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 67.
DE RecName: Full=Probable acridone synthase 4;
DE EC=2.3.1.159;
DE AltName: Full=Acridone synthase IV;
GN Name=ACS4;
OS Ruta graveolens (Common rue).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Sapindales; Rutaceae; Rutoideae; Ruta.
OX NCBI_TaxID=37565;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Immature flower;
RA Springob K., Matern U.;
RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA = 1,3-
CC dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O;
CC Xref=Rhea:RHEA:22224, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:30306, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57384, ChEBI:CHEBI:58630; EC=2.3.1.159;
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000305}.
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DR EMBL; AJ297787; CAC14057.1; -; mRNA.
DR AlphaFoldDB; Q9FSC1; -.
DR SMR; Q9FSC1; -.
DR GO; GO:0050635; F:acridone synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR InterPro; IPR018088; Chalcone/stilbene_synthase_AS.
DR InterPro; IPR011141; Polyketide_synthase_type-III.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11877; PTHR11877; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF00195; Chal_sti_synt_N; 1.
DR PIRSF; PIRSF000451; PKS_III; 1.
DR SUPFAM; SSF53901; SSF53901; 2.
DR PROSITE; PS00441; CHALCONE_SYNTH; 1.
PE 2: Evidence at transcript level;
KW Acyltransferase; Flavonoid biosynthesis; Transferase.
FT CHAIN 1..391
FT /note="Probable acridone synthase 4"
FT /id="PRO_0000216089"
FT ACT_SITE 164
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10023"
SQ SEQUENCE 391 AA; 42710 MW; DA6453B857D4C87B CRC64;
MESLKEMRKA QMSEGPAAIL AIGTATPNNV YMQADYPDYY FRMTKSEHMT ELKDKFRTLC
EKSMIRKRHM CFSEEFLKAN PEVSKHMGKS LNARQDIAVV ETPRLGNEAA VKAIKEWGQP
KSSITHLIFC SSAGVDMPGA DYQLTRILGL NPSVKRMMVY QQGCYAGGTV LRLAKDLAEN
NKGSRVLVVC SELTAPTFRG PSPDAVDSLV GQALFADGAA ALVVGADPDS SIERALYYLV
SASQMLLPDS DGAIEGHIRE EGLTVHLKKD VPALFSANID TPLVEAFKPL GISDWNSIFW
IAHPGGPAIL DQIEEKLGLK EDKLRASKHV MSEYGNMSSS CVLFVLDEMR SRSLQDGKST
TGEGLDWGVL FGFGPGLTVE TVVLRSVPIE A