CYC22_CAEEL
ID CYC22_CAEEL Reviewed; 123 AA.
AC Q23240;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Probable cytochrome c 2.2;
GN Name=cyc-2.2; ORFNames=ZC116.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Electron carrier protein. The oxidized form of the cytochrome
CC c heme group can accept an electron from the heme group of the
CC cytochrome c1 subunit of cytochrome reductase. Cytochrome c then
CC transfers this electron to the cytochrome oxidase complex, the final
CC protein carrier in the mitochondrial electron-transport chain (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000250}.
CC Note=Loosely associated with the inner membrane. {ECO:0000250}.
CC -!- PTM: Binds 1 heme c group covalently per subunit. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the cytochrome c family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=Life shuttle - Issue 76 of
CC November 2006;
CC URL="https://web.expasy.org/spotlight/back_issues/076";
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DR EMBL; Z74046; CAA98555.1; -; Genomic_DNA.
DR PIR; T27492; T27492.
DR RefSeq; NP_506156.1; NM_073755.3.
DR AlphaFoldDB; Q23240; -.
DR SMR; Q23240; -.
DR BioGRID; 44748; 12.
DR STRING; 6239.ZC116.2; -.
DR EPD; Q23240; -.
DR PaxDb; Q23240; -.
DR PeptideAtlas; Q23240; -.
DR EnsemblMetazoa; ZC116.2.1; ZC116.2.1; WBGene00013854.
DR GeneID; 179728; -.
DR KEGG; cel:CELE_ZC116.2; -.
DR CTD; 179728; -.
DR WormBase; ZC116.2; CE06565; WBGene00013854; cyc-2.2.
DR eggNOG; KOG3453; Eukaryota.
DR GeneTree; ENSGT00940000168884; -.
DR HOGENOM; CLU_060944_3_1_1; -.
DR InParanoid; Q23240; -.
DR OMA; YSDAMKN; -.
DR OrthoDB; 1533604at2759; -.
DR PhylomeDB; Q23240; -.
DR Reactome; R-CEL-111457; Release of apoptotic factors from the mitochondria.
DR Reactome; R-CEL-3299685; Detoxification of Reactive Oxygen Species.
DR Reactome; R-CEL-5620971; Pyroptosis.
DR PRO; PR:Q23240; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00013854; Expressed in adult organism and 1 other tissue.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IBA:GO_Central.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; IBA:GO_Central.
DR GO; GO:0006122; P:mitochondrial electron transport, ubiquinol to cytochrome c; IBA:GO_Central.
DR GO; GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IBA:GO_Central.
DR Gene3D; 1.10.760.10; -; 1.
DR InterPro; IPR009056; Cyt_c-like_dom.
DR InterPro; IPR036909; Cyt_c-like_dom_sf.
DR InterPro; IPR002327; Cyt_c_1A/1B.
DR PANTHER; PTHR11961; PTHR11961; 1.
DR Pfam; PF00034; Cytochrom_C; 1.
DR PRINTS; PR00604; CYTCHRMECIAB.
DR SUPFAM; SSF46626; SSF46626; 1.
DR PROSITE; PS51007; CYTC; 1.
PE 3: Inferred from homology;
KW Electron transport; Heme; Iron; Metal-binding; Mitochondrion;
KW Reference proteome; Respiratory chain; Transport.
FT CHAIN 1..123
FT /note="Probable cytochrome c 2.2"
FT /id="PRO_0000108272"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 30
FT /ligand="heme c"
FT /ligand_id="ChEBI:CHEBI:61717"
FT /note="covalent"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00433"
FT BINDING 33
FT /ligand="heme c"
FT /ligand_id="ChEBI:CHEBI:61717"
FT /note="covalent"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00433"
FT BINDING 34
FT /ligand="heme c"
FT /ligand_id="ChEBI:CHEBI:61717"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00433"
FT BINDING 95
FT /ligand="heme c"
FT /ligand_id="ChEBI:CHEBI:61717"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00433"
SQ SEQUENCE 123 AA; 13362 MW; 6FBC24AF847F596C CRC64;
MGKKKSDTAS GGAIPEGDNE KGKKIFKQRC EQCHVVNSLQ TKTGPTLNGV IGRQSGQVAG
FDYSAANKNK GVVWDRQTLF DYLADPKKYI PGTKMVFAGL KKADERADLI KFIEVEAAKK
PSA
