CYC4_PSEAE
ID CYC4_PSEAE Reviewed; 201 AA.
AC P00106;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 08-DEC-2000, sequence version 3.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Cytochrome c4;
DE Flags: Precursor;
GN Name=cc4; OrderedLocusNames=PA5490;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
RN [2]
RP PROTEIN SEQUENCE OF 21-201.
RA Ambler R.P.;
RL Submitted (MAY-1995) to UniProtKB.
CC -!- FUNCTION: Diheme, high potential cytochrome c believed to be an
CC intermediate electron donor to terminal oxidation systems.
CC -!- SUBCELLULAR LOCATION: Periplasm.
CC -!- PTM: Binds 2 heme c groups covalently per subunit.
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DR EMBL; AE004091; AAG08875.1; -; Genomic_DNA.
DR PIR; A00098; CCPS4A.
DR PIR; A82961; A82961.
DR RefSeq; NP_254177.1; NC_002516.2.
DR RefSeq; WP_003102831.1; NZ_QZGE01000012.1.
DR PDB; 6Q2U; X-ray; 1.85 A; A=21-201.
DR PDBsum; 6Q2U; -.
DR AlphaFoldDB; P00106; -.
DR SMR; P00106; -.
DR STRING; 287.DR97_2868; -.
DR PaxDb; P00106; -.
DR PRIDE; P00106; -.
DR DNASU; 877732; -.
DR EnsemblBacteria; AAG08875; AAG08875; PA5490.
DR GeneID; 877732; -.
DR KEGG; pae:PA5490; -.
DR PATRIC; fig|208964.12.peg.5755; -.
DR PseudoCAP; PA5490; -.
DR HOGENOM; CLU_076280_2_1_6; -.
DR InParanoid; P00106; -.
DR OMA; AGCHSPN; -.
DR PhylomeDB; P00106; -.
DR BioCyc; PAER208964:G1FZ6-5617-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; ISS:PseudoCAP.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR Gene3D; 1.10.760.10; -; 2.
DR InterPro; IPR009056; Cyt_c-like_dom.
DR InterPro; IPR036909; Cyt_c-like_dom_sf.
DR InterPro; IPR024167; Cytochrome_c4-like.
DR Pfam; PF00034; Cytochrom_C; 2.
DR PIRSF; PIRSF000005; Cytochrome_c4; 1.
DR SUPFAM; SSF46626; SSF46626; 2.
DR PROSITE; PS51007; CYTC; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Electron transport; Heme; Iron;
KW Metal-binding; Periplasm; Reference proteome; Signal; Transport.
FT SIGNAL 1..20
FT /evidence="ECO:0000269|Ref.2"
FT CHAIN 21..201
FT /note="Cytochrome c4"
FT /id="PRO_0000006508"
FT BINDING 34
FT /ligand="heme c"
FT /ligand_id="ChEBI:CHEBI:61717"
FT /ligand_label="1"
FT /note="covalent"
FT BINDING 37
FT /ligand="heme c"
FT /ligand_id="ChEBI:CHEBI:61717"
FT /ligand_label="1"
FT /note="covalent"
FT BINDING 38
FT /ligand="heme c"
FT /ligand_id="ChEBI:CHEBI:61717"
FT /ligand_label="1"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT BINDING 77
FT /ligand="heme c"
FT /ligand_id="ChEBI:CHEBI:61717"
FT /ligand_label="1"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT BINDING 130
FT /ligand="heme c"
FT /ligand_id="ChEBI:CHEBI:61717"
FT /ligand_label="2"
FT /note="covalent"
FT BINDING 133
FT /ligand="heme c"
FT /ligand_id="ChEBI:CHEBI:61717"
FT /ligand_label="2"
FT /note="covalent"
FT BINDING 134
FT /ligand="heme c"
FT /ligand_id="ChEBI:CHEBI:61717"
FT /ligand_label="2"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT BINDING 178
FT /ligand="heme c"
FT /ligand_id="ChEBI:CHEBI:61717"
FT /ligand_label="2"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT CONFLICT 86..87
FT /note="DQ -> NE (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT HELIX 24..30
FT /evidence="ECO:0007829|PDB:6Q2U"
FT HELIX 31..34
FT /evidence="ECO:0007829|PDB:6Q2U"
FT HELIX 35..38
FT /evidence="ECO:0007829|PDB:6Q2U"
FT HELIX 57..68
FT /evidence="ECO:0007829|PDB:6Q2U"
FT HELIX 75..77
FT /evidence="ECO:0007829|PDB:6Q2U"
FT TURN 78..80
FT /evidence="ECO:0007829|PDB:6Q2U"
FT HELIX 86..98
FT /evidence="ECO:0007829|PDB:6Q2U"
FT TURN 108..110
FT /evidence="ECO:0007829|PDB:6Q2U"
FT HELIX 111..120
FT /evidence="ECO:0007829|PDB:6Q2U"
FT HELIX 123..125
FT /evidence="ECO:0007829|PDB:6Q2U"
FT HELIX 130..132
FT /evidence="ECO:0007829|PDB:6Q2U"
FT HELIX 154..165
FT /evidence="ECO:0007829|PDB:6Q2U"
FT TURN 173..176
FT /evidence="ECO:0007829|PDB:6Q2U"
FT HELIX 177..182
FT /evidence="ECO:0007829|PDB:6Q2U"
FT HELIX 187..198
FT /evidence="ECO:0007829|PDB:6Q2U"
SQ SEQUENCE 201 AA; 20735 MW; E829B7B8F361F7B5 CRC64;
MNKLLVSLLL TLGLTGLAHA AGDAAAGQAK AAVCGACHGA DGNSPAPNFP KLAGQGERYL
LKQMHDIKDG KRTVLEMTGL LTNLSDQDLA DIAAYFASQK MSVGMADPNL VAQGEALFRG
GKIAEGMPAC TGCHSPSGVG IATAGFPHLG GQHATYVAKQ LTDFREGTRT NDGDTKIMQS
IAAKLSNKDI AAISSYIQGL H
